Feifei Zhang
Associate Research Scientist in GeneticsAbout
Research
Publications
2026
The salience network, depression, and exercise dependence in middle-aged and older adults: A structural MRI study
Zhang F, Shao Y, Jia Z, Wang X. The salience network, depression, and exercise dependence in middle-aged and older adults: A structural MRI study. Brain Research Bulletin 2026, 236: 111770. PMID: 41663036, DOI: 10.1016/j.brainresbull.2026.111770.Peer-Reviewed Original ResearchConceptsSymptoms of exercise dependenceSalience networkGray matter volumeExercise dependenceParticipants' overall healthOlder adultsExercise dependence symptomsStructural connectivityStructural MRI studiesStructural brain networksMiddle-agedDependence symptomsMatter volumeBrain pathwaysBrain networksGroup differencesPsychological symptomsPaper-based questionnaireMediation analysisExcessive exerciseHealthy participantsDepressionExercise guidelinesPhysical activityEmotional states
2025
Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure
Li Y, Zhang F, Liu B, Wang X, Meng H, Niu Q, Zhang H, Tan Y. Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure. Scientific Reports 2025, 15: 45010. PMID: 41275008, PMCID: PMC12748568, DOI: 10.1038/s41598-025-29829-y.Peer-Reviewed Original ResearchGray matter volumeAuditory Verbal Learning TestMild cognitive impairmentTrail Making TestCaudate nucleusRey Auditory Verbal Learning TestWhole-brain gray matter volumeCognitive impairmentCaudate nucleus atrophyVerbal Learning TestAssociated with cognitive declineBilateral caudate nucleusNeuroimaging featuresLearning TestMontreal Cognitive AssessmentNeuroanatomical mechanismsMatter volumeTMT-AError responsesStructural MRIMediation analysisWhole-brainCognitive AssessmentCognitive declineGrading patternsCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersEffectiveness of digital screening tools in detecting cognitive impairment among community-dwelling elderly in Northern China: A large cohort study
Zhang X, Zhang F, Hou S, Hao C, Fan X, Zhao Y, Bao W, An J, Du S, Min G, Wang Q, Zhu W, Li Y, Zhang H. Effectiveness of digital screening tools in detecting cognitive impairment among community-dwelling elderly in Northern China: A large cohort study. The Journal Of Prevention Of Alzheimer's Disease 2025, 12: 100080. PMID: 39922758, PMCID: PMC12184026, DOI: 10.1016/j.tjpad.2025.100080.Peer-Reviewed Original ResearchConceptsDigital screening toolArea under the curvePlasma P-tau217 levelsScreening toolMild cognitive impairmentCognitive impairmentCommunity-Dwelling Elderly IndividualsCohort studyCommunity-based cohort studyNormal controlsCohort of community-dwelling elderly individualsCommunity-dwellingP-tau217 levelsCommunity settingsElderly individualsGaitCohortImpairment
2024
The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratumGenes associated with cortical thickness alterations in behavioral addiction
Xie H, Wang Y, Zhu F, Zhang F, Wu B, Zhao Z, Gan R, Gong Q, Jia Z. Genes associated with cortical thickness alterations in behavioral addiction. Cerebral Cortex 2024, 34: bhae298. PMID: 39051658, DOI: 10.1093/cercor/bhae298.Peer-Reviewed Original ResearchConceptsBehavioral addictionsCortical thicknessBehavioral regulationPostcentral gyrusCompulsive reward-seeking behaviorReward-seeking behaviorDorsolateral prefrontal cortexDopamine D2 receptorsAllen Human Brain AtlasOrbital-frontal cortexCortical thickness alterationsHuman Brain AtlasAddiction phenotypesAddiction severityPrefrontal cortexD2 receptorsDopamine metabolismBrain areasNeurogenetic mechanismsAddictionThickness alterationsPrecuneusGyrusDopamineResponse to stimuliBody Satisfaction, Exercise Dependence, and White Matter Microstructure in Young Adults
Xie H, Zhang F, Gan S, Wu J, Wu B, Qin K, Wang S, Sweeney J, Gong Q, Jia Z. Body Satisfaction, Exercise Dependence, and White Matter Microstructure in Young Adults. Journal Of Magnetic Resonance Imaging 2024, 61: 749-755. PMID: 38874990, DOI: 10.1002/jmri.29485.Peer-Reviewed Original ResearchExercise Dependence ScaleTract-based spatial statisticsWhite matter microstructureEDS scoresExercise dependenceBody shape satisfactionNeuropsychological mechanismsRight cingulumFA valuesWhole-brain tract-based spatial statisticsFractional anisotropyBody satisfactionLeft inferior frontal-occipital fasciculusQuantitative anisotropyInferior frontal occipital fasciculusFrontal-subcorticalBilateral corticospinal tractsNeural signaturesSuperior thalamic radiationSensorimotor networkDependence ScaleThalamic radiationCorrelational tractographyTractography analysisQA valuesDecoupling of gray and white matter functional networks in cognitive impairment induced by occupational aluminum exposure
Zhang F, Li L, Liu B, Shao Y, Tan Y, Niu Q, Zhang H. Decoupling of gray and white matter functional networks in cognitive impairment induced by occupational aluminum exposure. NeuroToxicology 2024, 103: 1-8. PMID: 38777096, DOI: 10.1016/j.neuro.2024.05.001.Peer-Reviewed Original ResearchExecutive control networkFunctional connectivityCognitive impairmentCognitive functionTrail Making Test Part AResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingControl networkDecreased FCsReduced functional connectivityGray matterHuman cognitive functionsCognitive impairment groupExecutive controlNeurobiological mechanismsLimbic networkMontreal Cognitive AssessmentWhite matterCognitive AssessmentImpairment groupFunctional networksMagnetic resonance imagingImpairmentPart ACognitionDisrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts
Li H, Zhang H, Qin K, Yin L, Chen Z, Zhang F, Wu B, Chen T, Sweeney J, Gong Q, Jia Z. Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts. Brain Imaging And Behavior 2024, 18: 741-752. PMID: 38407738, DOI: 10.1007/s11682-024-00870-1.Peer-Reviewed Original ResearchNon-suicidal depressed patientsSuicidal depressed patientsDepressed patientsSuicide planNodal efficiencyHealthy controlsMedial orbitofrontal cortexWhite matter structural networksDecreased nodal efficiencyProximal risk factorsWhite matter networksGraph theory analysisOrbitofrontal cortexSuicide brainDiffusion tensor imagingRolandic operculumOlfactory cortexStructural networkNodal network propertiesMotor areaDeterministic tractographySuicideLocal efficiencyTensor imagingStructural connectomeNeuropsychological insights into exercise addiction: the role of brain structure and self-efficacy in middle-older individuals
Zhang F, Shao Y, Zhang X, Zhang H, Tan Y, Yang G, Wang X, Jia Z, Gong Q, Zhang H. Neuropsychological insights into exercise addiction: the role of brain structure and self-efficacy in middle-older individuals. Cerebral Cortex 2024, 34: bhad514. PMID: 38186007, DOI: 10.1093/cercor/bhad514.Peer-Reviewed Original ResearchGray matter volumeRight inferior temporal regionMatter volumeInferior temporal regionsBrain structuresExercise addictionTemporal regionsStructural magnetic resonance imagingMagnetic resonance imagingLeft rolandic operculumSPM12 softwareDevelopment of interventionsRight hippocampusStudy populationRolandic operculumResonance imagingBehavioral assessmentPhysiological changesAddictionNeuropsychological mechanismsPsychological factorsPositive correlationNegative correlationMediation analysisIndividuals