https://websites4-live-prod.ysmdevs.com/genetics/news-rss/?orgId=119354&title=Latest+News A selection of the latest research, academic, and other newsworthy developments at Yale Center for Genomic Health en-us Copyright 2026 Yale School of Medicine Thu, 14 May 2026 20:13:22 Z https://news.yale.edu/2025/07/02/change-trackers-new-consortium-catalog-dna-mutations-across-human-lifetime https://news.yale.edu/2025/07/02/change-trackers-new-consortium-catalog-dna-mutations-across-human-lifetime In a multi-institution project, scientists will track genetic mutations occurring across the lifetime of 150 healthy individuals with the aim of understanding how they affect development, aging, and disease. Thu, 03 Jul 2025 18:00:00 Z https://engineering.yale.edu/news-and-events/news/ai-tool-set-transform-characterization-and-treatment-cancers https://engineering.yale.edu/news-and-events/news/ai-tool-set-transform-characterization-and-treatment-cancers Researchers have developed a new AI tool which could be integrated into cancer diagnostics to better inform treatment. Tue, 24 Jun 2025 17:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/cannabis-use-disorder-may-increase-risk-for-certain-psychiatric-illnesses/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/cannabis-use-disorder-may-increase-risk-for-certain-psychiatric-illnesses/ People with certain psychiatric disorders—including schizophrenia, bipolar disorder, anxiety, and PTSD—are at increased risk for cannabis use disorder and vice versa, a new study finds. Mon, 09 Jun 2025 20:00:00 Z https://www.nature.com/articles/s44220-025-00440-4 https://www.nature.com/articles/s44220-025-00440-4 A new Yale genetics study, published in Nature Mental Health, provides evidence on the relationship between cannabis use, cannabis use disorder, and a range of psychiatric disorders. The authors include first author Marco Galimberti, PhD, left, and senior author Joel Gelernter, MD, right. Thu, 29 May 2025 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-scientists-uncover-sex-differences-in-recalling-and-reporting-of-family-history-of-alzheimers-disease/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-scientists-uncover-sex-differences-in-recalling-and-reporting-of-family-history-of-alzheimers-disease/ Investigators in the Yale Department of Psychiatry demonstrated that females and males report differently information regarding family history of Alzheimer’s disease. In particular, the scientists observed that socioeconomic factors and cognitive abilities contribute to altering the assessment of family history of Alzheimer’s disease in large-scale studies. Tue, 27 May 2025 04:00:00 Z https://www.nytimes.com/2025/05/08/well/biological-age-faceage.html?searchResultPosition=3 https://www.nytimes.com/2025/05/08/well/biological-age-faceage.html?searchResultPosition=3 Yale School of Medicine's Jennifer E. Miller, PhD, associate professor of medicine (general medicine), voices concerns about an AI tool designed to assess a patient's health. Thu, 08 May 2025 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/the-massilani-lab-at-yale-school-of-medicine/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/the-massilani-lab-at-yale-school-of-medicine/ The Massilani Lab, led by Diyendo Massilani, PhD, assistant professor of genetics, investigates the evolutionary history of modern and extinct human populations using ancient DNA. Wed, 23 Apr 2025 12:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/genetic-clues-could-inform-precision-medicine-for-schizophrenia-and-autism/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/genetic-clues-could-inform-precision-medicine-for-schizophrenia-and-autism/ Different mutations in the same gene inform how to tailor treatments for patients with schizophrenia and autism, according to new research from Yale School of Medicine. Wed, 16 Apr 2025 15:00:00 Z https://ventures.yale.edu/news/blavatnik-fund-innovation-yale-support-15-breakthrough-interventions-cardiometabolic https://ventures.yale.edu/news/blavatnik-fund-innovation-yale-support-15-breakthrough-interventions-cardiometabolic This year’s awardees are tackling some of the most urgent life science challenges with projects spanning novel therapeutics to AI-powered medical solutions. Fri, 28 Feb 2025 05:00:00 Z https://www.wtnh.com/news/health/rare-disease-day-scientists-trying-to-solve-over-7k-rare-diseases/ https://www.wtnh.com/news/health/rare-disease-day-scientists-trying-to-solve-over-7k-rare-diseases/ Dr. Michele Spencer-Manzon, a Yale Medicine pediatric geneticist and associate professor at the Yale School of Medicine, joined Good Morning Connecticut to discuss Rare Disease Day and the over 7,000 rare diseases scientists are trying to solve. Fri, 28 Feb 2025 05:00:00 Z https://news.yale.edu/2025/02/19/immune-markers-post-vaccination-syndrome-indicate-future-research-directions https://news.yale.edu/2025/02/19/immune-markers-post-vaccination-syndrome-indicate-future-research-directions A small number of people report chronic symptoms after receiving COVID-19 shots. A new study provides clues for further research. Wed, 19 Feb 2025 05:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/the-future-of-gene-editing-treatments-for-rare-diseases/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/the-future-of-gene-editing-treatments-for-rare-diseases/ New gene-editing treatments being developed at Yale School of Medicine give hope to those with rare genetic diseases, such as Angelman syndrome. Mon, 17 Feb 2025 05:00:00 Z https://www.yalemedicine.org/news/yale-dermatologist-looks-to-science https://www.yalemedicine.org/news/yale-dermatologist-looks-to-science A Yale Medicine dermatologist explains how looking at the skin through a scientific lens can help treat even the most complex skin conditions. Tue, 11 Feb 2025 05:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/rare-disease-celebration-feb-21/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/rare-disease-celebration-feb-21/ Yale School of Medicine, the Department of Genetics, Yale New Haven Health, and the National Organization for Rare Disorders are hosting a Rare Disease Celebration on Friday, Feb. 21 from 1 – 5 p.m. at the Greenberg Conference Center. Thu, 06 Feb 2025 05:00:00 Z https://news.yale.edu/2025/02/06/study-sheds-light-genetic-changes-shaped-human-brain-evolution https://news.yale.edu/2025/02/06/study-sheds-light-genetic-changes-shaped-human-brain-evolution A new Yale study reveals how a class of genetic switches altered genes shared by humans and chimpanzees, and identified more genes that were targeted in the process. Thu, 06 Feb 2025 05:00:00 Z https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)00062-9/fulltext https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)00062-9/fulltext Yale Department of Psychiatry researchers Lu Wang, PhD; Hang Zhou, PhD; and Joel Gelernter, MD, are co-authors of a paper in Biological Psychiatry that extends understanding of the genetic architecture of alcohol use disorder. Thu, 30 Jan 2025 05:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/this-faster-low-tech-test-identifies-rare-disease-causing-genetic-mutations/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/this-faster-low-tech-test-identifies-rare-disease-causing-genetic-mutations/ A new, cost-effective method can be used to test whether DNA variants can lead to a rare family of neuromuscular diseases, Yale researchers have found. Mon, 02 Dec 2024 05:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/generative-ai-designs-dna-sequences-to-switch-genes-on-and-off/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/generative-ai-designs-dna-sequences-to-switch-genes-on-and-off/ A newly developed AI platform designs DNA sequences never seen in nature, which could lead to improved gene therapies. Wed, 23 Oct 2024 15:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-scientists-uncover-genetic-predisposition-to-anxiety/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-scientists-uncover-genetic-predisposition-to-anxiety/ Investigators in the Yale Department of Psychiatry investigated the genetic profiles of more than 1 million participants enrolled in multiple cohorts around the world. Leveraging this large dataset, they uncovered more than 100 genes associated with anxiety. Eleni Friligkou, MD, MSc, and Renato Polimanti, PhD, MSc, are first and senior authors, respectively. Thu, 19 Sep 2024 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/nih-recognizes-yales-expertise-in-the-genetics-of-rare-disease/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/nih-recognizes-yales-expertise-in-the-genetics-of-rare-disease/ A new Yale Diagnostic Center of Excellence will work to bring diagnostic genetic services to underserved patients with rare diseases. Tue, 10 Sep 2024 17:50:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/a-genome-wide-investigation-into-the-underlying-genetic-architecture-of-personality-traits-and-overlap-with-psychopathology/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/a-genome-wide-investigation-into-the-underlying-genetic-architecture-of-personality-traits-and-overlap-with-psychopathology/ Yale scientists, led by first author Priya Gupta, PhD, postdoctoral associate, and senior author Daniel F. Levey, PhD, assistant professor of psychiatry, investigated the complex underlying genetic architecture of the "big five" personality traits in a cohort of 682,688 people, the largest study of its kind. The results were published in Nature Human Behavior. Thu, 15 Aug 2024 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/human-genetics-and-epigenetics-of-alcohol-use-disorder/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/human-genetics-and-epigenetics-of-alcohol-use-disorder/ Hang Zhou, PhD, assistant professor of psychiatry, and Joel Gelernter, MD, Foundations Fund Professor of Psychiatry and professor of genetics and of neuroscience, are co-authors of a paper in The Journal of Clinical Investigation that reviews progress of human genetic and epigenetic study of alcohol use disorder and summarizes key future directions including applications of whole-genome sequencing, multi-omics and data science approaches. Thu, 15 Aug 2024 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/polycystic-kidney-disease-treatment-gene-target-identified/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/polycystic-kidney-disease-treatment-gene-target-identified/ An unsuspected gene, Glis2, has been found to be a target of polycystic kidney disease (PKD) signaling in preclinical models. Fri, 07 Jun 2024 04:00:00 Z https://www.businessinsider.com/neanderthals-virus-herpes-hpv-caught-from-humans-may-helped-extinction-2024-6 https://www.businessinsider.com/neanderthals-virus-herpes-hpv-caught-from-humans-may-helped-extinction-2024-6 Neanderthals may have suffered from some very familiar diseases 50,000 years ago, which could have contributed to their downfall. Researchers studying ancient Neanderthal DNA found traces of three viruses that cause colds, cold sores, genital warts, and cancer. Thu, 06 Jun 2024 04:00:00 Z https://www.nbcnews.com/health/health-news/genetic-disorder-may-cause-intellectual-disability-rcna154470 https://www.nbcnews.com/health/health-news/genetic-disorder-may-cause-intellectual-disability-rcna154470 A newly identified neurodevelopmental disorder may explain tens of thousands of cases of intellectual disability whose cause was previously unknown, according to a new study. Fri, 31 May 2024 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/single-cell-genomics-and-regulatory-networks-for-388-human-brains/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/single-cell-genomics-and-regulatory-networks-for-388-human-brains/ Yale researchers who conducted the largest human brain analysis from a single-cell perspective hope their findings lead to better prediction of medicine that will target certain cells. Fri, 24 May 2024 04:00:00 Z https://www.nature.com/articles/s41380-024-02548-y https://www.nature.com/articles/s41380-024-02548-y Marco Galimberti, PhD, postdoctoral associate, and Joel Gelernter, MD, Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience, are first and senior authors, respectively, of a paper on Molecular Psychiatry that investigates the genetic architecture and causal relationships between cannabis use disorder and lifetime cannabis use with risk for developing substance use disorders and substance use traits. Fri, 05 Apr 2024 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/journals/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/journals/ A collection of recent studies from YSM Wed, 20 Mar 2024 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/endometriosis/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/endometriosis/ New research is revealing that endometriosis is not just a gynecologic disease, but rather a widespread inflammatory disorder. Wed, 20 Mar 2024 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/the-power-of-collaboration/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/the-power-of-collaboration/ An openness to collaboration is just one factor in the popularity of team science at YSM. Wed, 20 Mar 2024 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/digital-pathology/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/digital-pathology/ Yale School of Medicine's Department of Pathology has entered the booming field of digital pathology. Wed, 20 Mar 2024 04:00:00 Z https://news.yale.edu/2024/03/19/understanding-wiring-human-genome https://news.yale.edu/2024/03/19/understanding-wiring-human-genome If the human genome is like the blueprint for a house, a new study on the non-coding parts of DNA maps the wiring—connecting the lights to their switches. Tue, 19 Mar 2024 21:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/new-frontiers-in-obesity-research-at-yale/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/new-frontiers-in-obesity-research-at-yale/ Newly emerging, highly effective treatments and new discoveries regarding the pathophysiology of obesity provide promise for combating this growing epidemic. Wed, 06 Mar 2024 05:00:00 Z https://site.autismadvocateparentingmagazine.com/wp-content/uploads/2024/01/Researchers_Investigate_Head_Size_and_Autism-789842.pdf https://site.autismadvocateparentingmagazine.com/wp-content/uploads/2024/01/Researchers_Investigate_Head_Size_and_Autism-789842.pdf A recent study led by Dr. Flora Vaccarino explored the different cell types in cortical organoids to gain a better understanding of the development of macrocephaly in autistic individuals. Fri, 05 Jan 2024 05:00:00 Z https://news.yale.edu/2023/11/20/genomic-study-links-cannabis-abuse-multiple-health-problems https://news.yale.edu/2023/11/20/genomic-study-links-cannabis-abuse-multiple-health-problems A Yale-led analysis of the genomes of more than 1 million people has shed light on the underlying biology of cannabis use disorder and associated risks. Mon, 20 Nov 2023 17:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/multi-ancestry-genome-wide-association-study-of-cannabis-use-disorder-yields-insight-into-disease-biology-and-public-health-implications/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/multi-ancestry-genome-wide-association-study-of-cannabis-use-disorder-yields-insight-into-disease-biology-and-public-health-implications/ In a landmark research study, scientists have unveiled the results of a comprehensive genome-wide association study (GWAS), published in Nature Genetics, shedding new light on the genetic factors underlying cannabis use disorders (CanUD) and their potential link to lung cancer. Mon, 20 Nov 2023 05:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-study-finds-genetic-links-between-some-diseases-and-ptsd/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/yale-study-finds-genetic-links-between-some-diseases-and-ptsd/ A new study led by Yale Department of Psychiatry researchers and published in JAMA Psychiatry has identified numerous physical health conditions, particularly diseases of the cardiovascular and respiratory systems, that have genetic links to post-traumatic stress disorder (PTSD). Gita Pathak, PhD, and Renato Polimanti, PhD, are first and senior authors, respectively. Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/skin-in-the-game/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/skin-in-the-game/ Skin in the game: A physician-scientist's passions Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/getting-it-right-with-medical-ai/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/getting-it-right-with-medical-ai/ Getting it “right” with medical AI Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/supersize-the-cell/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/supersize-the-cell/ A breakthrough microscopy technique now enables researchers to observe previously unseen molecular processes within genetic material. Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/letters/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/letters/ These letters to the editor address Dr. Howard Pearson's legacy and dyslexia research at Yale. Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/from-the-journals/ https://medicine.yale.edu/ysm/news/yale-medicine-magazine/article/from-the-journals/ A genetic variant that is linked to faster progression of multiple sclerosis (MS) has been identified in a genome-wide association study. Wed, 01 Nov 2023 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/visualizing-publication-trends-for-scientists/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/visualizing-publication-trends-for-scientists/ Introducing ScholarTrends, an R Shiny application that produces seven interpretable graphics summarizing a scientist’s entire publication history. This tool adds transparency to a researcher’s trajectory and makes it more accessible to quickly understand a person’s publication trends. Mon, 09 Oct 2023 13:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/large-nih-grant-supports-crispr-based-gene-therapy-development-for-brain-diseases/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/large-nih-grant-supports-crispr-based-gene-therapy-development-for-brain-diseases/ The two-phase grant will support research into a novel CRISPR-based gene-editing technology and delivery platform for targeting neurogenetic diseases. Tue, 03 Oct 2023 14:00:00 Z https://yaledailynews.com/blog/2023/10/03/placental-examination-might-be-able-to-explain-unaccounted-pregnancy-losses-yale-researchers-say/ https://yaledailynews.com/blog/2023/10/03/placental-examination-might-be-able-to-explain-unaccounted-pregnancy-losses-yale-researchers-say/ Yale researchers published a study last month revealing that over 90 percent of unaccounted pregnancy losses can be explained by placental examination. Tue, 03 Oct 2023 05:44:00 Z https://www.npr.org/2023/09/27/1202128281/a-new-study-shows-how-certain-genes-can-cause-brain-disorders-like-autism https://www.npr.org/2023/09/27/1202128281/a-new-study-shows-how-certain-genes-can-cause-brain-disorders-like-autism Kristen Brennand, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry, was a guest on NPR's "All Things Considered" program discussing how improved genetic understanding could lead to better medical diagnoses of patients. Mon, 02 Oct 2023 04:00:00 Z https://www.nature.com/articles/s41467-023-41249-y https://www.nature.com/articles/s41467-023-41249-y Joel Gelernter, MD, Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience, is senior author of a paper in Nature Communications that presents genome-wide association studies of short and long sleep duration in adults. Thu, 28 Sep 2023 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/huckins-to-receive-2023-international-society-of-psychiatric-genetics-theodore-reich-early-career-award/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/huckins-to-receive-2023-international-society-of-psychiatric-genetics-theodore-reich-early-career-award/ Laura Huckins, PhD, associate professor of psychiatry, has been awarded the 2023 International Society of Psychiatric Genetics (ISPG) Theodore Reich Early Career Award. Huckins was selected for the award based on her published work describing the genetic underpinnings of eating disorders and PTSD as well as for her service to the psychiatric genetics community. Wed, 20 Sep 2023 04:00:00 Z https://websites4-live-prod.ysmdevs.com/genetics/news-article/mitochondrial-function-beyond-serving-as-the-powerhouse-of-the-cell/ https://websites4-live-prod.ysmdevs.com/genetics/news-article/mitochondrial-function-beyond-serving-as-the-powerhouse-of-the-cell/ A new study shows that mitochondria help determine what undifferentiated cells in a growing embryo eventually will become. The study reveals a new underlying biological mechanism of mitochondrial metabolism and has important implications for treating diseases such as cancer. Fri, 15 Sep 2023 04:00:00 Z https://www.ctpublic.org/news/2023-09-07/yale-researchers-find-two-types-of-autism-underscoring-the-need-for-different-treatments https://www.ctpublic.org/news/2023-09-07/yale-researchers-find-two-types-of-autism-underscoring-the-need-for-different-treatments Researchers at the Yale School of Medicine’s Child Study Center have discovered at least two different types of autism. The findings, published in the journal Nature Neuroscience, suggest a need for more than just one drug to treat symptoms. Thu, 07 Sep 2023 04:00:00 Z