Urinary Bladder, Phase II
A Phase II Study of Consolidative Local Therapy in Patients With Locally Advanced or Oligo-metastatic Urothelial Carcinoma (la/mUC) Following Treatment Response to Systemic Therapy With or Without Metastasis-directed Radiotherapy
Volunteers
Health Professionals
What is the purpose of this trial?
This study investigates the therapeutic benefit of consolidative local therapy with extirpative surgery for participants with locally advanced or oligo-metastatic urothelial carcinoma that have disease control with enfortumab vedotin-based systemic therapy and surgically resectable or previously radiated metastatic sites.
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alessia Donadio, MD
- Anca Bulgaru, MD
- Andrea Brennan, PA
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS, MD
- Benjamin Newton, MD
- Christina Santore, APRN
- Clarice Grens, APRN
- Curtis Jamison Perry, MD, PhD
- D. Barry Boyd, MD, MS
- Daniel P. Petrylak, MD
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Harold Tara Jr, MD
- Isaac Y. Kim, MD, PhD, MBA
- Jason Haldas, MD
- Johanna LaSala, MD
- Jose Morales-Marin
- Joseph Brito III, MD
- Joseph Kim, MD
- Joseph Renzulli, MD, FACS
- Karen Ann Hammond, DNP, APRN, ACNP (BC)
- Katherine Harvey, MD, MPH
- Kayla Martello
- Kert Sabbath, MD, FACP
- Kiran Turaga, MD, MPH
- Kristen Hoxie, PA
- Larisa Fleysher, APRN
- Laura Sabourin
- Lynn Mastrianni, APRN
- Madeline Santiago
- Matthew Austin, MD
- Meaghan Conway
- Michael Burke
- Michael Grant, MD
- Michael Hurwitz, MD, PhD
- Michael E. Karellas, MD, FACS
- Michael S. Leapman, MD, MHS
- Michelle Laspino, APRN
- Neal Fischbach, MD
- Osarugue Otasowie
- Preston C. Sprenkle, MD
- Rebecca Vanasse-Passas, MD
- Robert Legare, MD
- Robert Matera, MD
- Sara Anastasio, APRN, RN
- Sarah Carlson, PA
- Sarah Thomen, APRN
- Sharynn Hall, MD, PhD
- Stacey LaRosa, APRN
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy, APRN
- Wajih Kidwai, MD, FACP
- Wei Shen Tan, MD, PhD, FRCS
- William K. Oh, MD
- Yi An, MD
- Yifei Zhang, MD
- Last Updated02/17/2026
- Study IRB#2000039076