Yong-Lian Zhu, MD
Associate Research Scientist in Obstetrics, Gynecology, and Reproductive SciencesDownloadHi-Res Photo
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Associate Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
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Obstetrics, Gynecology & Reproductive Sciences
Associate Research ScientistPrimary
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Education & Training
- MD
- Zhejiang University (1982)
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Yong-Lian Zhu's published research.
Publications Timeline
A big-picture view of Yong-Lian Zhu's research output by year.
Priscilla Dannies, PhD
Elena Ratner, MD, MBA
Z. Ping Lin, PhD
Elias Lolis, PhD
Michael Hodsdon, MD, PhD
8Publications
71Citations
Publications
2025
Epithelial ovarian cancer perpetuates immunosuppression by upregulating regulatory T cells and adenosine signaling
Lin A, Moscarelli J, Zhu Y, Lin Z, Ratner E. Epithelial ovarian cancer perpetuates immunosuppression by upregulating regulatory T cells and adenosine signaling. Gynecologic Oncology 2025, 200: 206-207. DOI: 10.1016/j.ygyno.2025.04.267.Peer-Reviewed Original ResearchCorrection: CXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer
Lin A, Moscarelli J, Zhu Y, Lin Z, Ratner E. Correction: CXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer. Scientific Reports 2025, 15: 26787. PMID: 40702101, PMCID: PMC12287456, DOI: 10.1038/s41598-025-12693-1.Peer-Reviewed Original ResearchCXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer
Lin A, Moscarelli J, Zhu Y, Lin Z, Ratner E. CXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer. Scientific Reports 2025, 15: 20778. PMID: 40596479, PMCID: PMC12217468, DOI: 10.1038/s41598-025-06812-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH Keywords5'-NucleotidaseAdenosineAnimalsApyraseB7-H1 AntigenCarcinoma, Ovarian EpithelialCell Line, TumorChemokine CXCL10Disease Models, AnimalDisease ProgressionFemaleHumansImmune ToleranceInterferon-gammaMiceOvarian NeoplasmsReceptors, CXCR3Signal TransductionT-Lymphocytes, RegulatoryTumor MicroenvironmentConceptsEpithelial ovarian cancerImmunosuppressive tumor microenvironmentRegulatory T cellsAdenosine signalingTumor microenvironmentTumor ascitesOvarian cancerT cellsAnti-cancer immune responseEffector T cell activationUp-regulation of Foxp3Epithelial ovarian cancer progressionProgression of epithelial ovarian cancerCell-mediated suppressionSyngeneic mouse modelT cell activationPEO1 cellsPD-L1Inhibitor bevacizumabMouse survivalIL10 productionProlonged survivalPEO4 cellsAMG487 treatmentEOC cells
2009
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance
Baumann RP, Penketh PG, Ishiguro K, Shyam K, Zhu YL, Sartorelli AC. Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance. Biochemical Pharmacology 2009, 79: 1553-1561. PMID: 20005211, PMCID: PMC2885764, DOI: 10.1016/j.bcp.2009.12.004.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAlkylguanine-DNA alkyltransferaseDNA GO6-alkylguanine-DNA alkyltransferaseCell linesBase-catalyzed activationCellular protectionReductive activationCross-link lesionsTumor cell resistanceCultured cellsCell lethalityReductase enzymePosition of guanineDifferent tumor typesIntracellular activationAlkyltransferaseCell resistanceActivationEnzymeCytotoxic effectsCellsOxygen-deficient cellsHypoxic cellsOxygen-deficient conditions
2002
Aggregation of Human Wild-Type and H27A-Prolactin in Cells and in Solution: Roles of Zn2+, Cu2+, and pH
Sankoorikal B, Zhu Y, Hodsdon M, Lolis E, Dannies P. Aggregation of Human Wild-Type and H27A-Prolactin in Cells and in Solution: Roles of Zn2+, Cu2+, and pH. Endocrinology 2002, 143: 1302-1309. DOI: 10.1210/en.143.4.1302.Peer-Reviewed Original ResearchCitationsConceptsAtT20 cellsSecretory granulesFormation of secretory granulesHuman prolactinZn2+-binding siteTransfected AtT20 cellsCores of secretory granulesHuman wild-typeWild-type prolactinAcidic pHCOS cellsRecombinant human prolactinIntracellular compartmentsWild-typeBinding sitesRat prolactinCu2+Neutral pHProlactinRatio of Zn2Concentrations of hormonesAtT20Cells
2001
Acquisition of Lubrol Insolubility, a Common Step for Growth Hormone and Prolactin in the Secretory Pathway of Neuroendocrine Cells*
Lee M, Zhu Y, Chang J, Dannies P. Acquisition of Lubrol Insolubility, a Common Step for Growth Hormone and Prolactin in the Secretory Pathway of Neuroendocrine Cells*. Journal Of Biological Chemistry 2001, 276: 715-721. PMID: 11024038, DOI: 10.1074/jbc.m008530200.Peer-Reviewed Original ResearchCitationsMeSH KeywordsAnimalsAnti-Bacterial AgentsBrefeldin AChloroquineCOS CellsDinitrobenzenesEndoplasmic ReticulumEpidermal Growth FactorEstradiolHuman Growth HormoneHydrogen-Ion ConcentrationInsulinMacrolidesMutationPituitary GlandPolyethylene GlycolsProlactinProtein TransportRatsSecretory VesiclesSolubilitySubstrate SpecificityTumor Cells, CulturedUltracentrifugation
2000
Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor
Lee M, Zhu Y, Sun Z, Rhee H, Jeromin A, Roder J, Dannies P. Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor. Endocrinology 2000, 141: 3485-3492. PMID: 10965922, DOI: 10.1210/endo.141.9.7647.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSecretory pathwayEpidermal growth factorSynaptotagmin IIICyclophilin BGH4C1 cellsInduction of proteinsGrowth factorGlucose-regulated protein 94Rat pituitary GH4C1 cellsSecretory granulesSynaptosomal-associated proteinMessenger RNA accumulationMembrane proteinsPituitary GH4C1 cellsSynaptosomal associated proteinRNA accumulationPlasma membraneProtein AssociatedSpecific proteinsSynaptotagmin IHormone-treated cellsSNAP-25Protein 94Secretory granule accumulationCoordinate eventAccumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor*
Lee M, Zhu Y, Sun Z, Rhee H, Jeromin A, Roder J, Dannies P. Accumulation of Synaptosomal-Associated Protein of 25 kDa (SNAP-25) and Other Proteins Associated with the Secretory Pathway in GH4C1 Cells Upon Treatment with Estradiol, Insulin, and Epidermal Growth Factor*. Endocrinology 2000, 141: 3485-3492. DOI: 10.1210/en.141.9.3485.Peer-Reviewed Original ResearchConceptsSNAP-25Secretory pathwaySynaptosomal-associated proteinSynaptotagmin IIIEpidermal growth factorCyclophilin BTreatment of GH4C1 cellsSecretory granulesSecretory granule accumulationGH4C1 cellsGlucose-regulated protein 94Rat pituitary GH4C1 cellsHormone-treated cellsInduction of proteinsPituitary GH4C1 cellsSynaptotagmin IRNA accumulationPlasma membraneSynaptotagminMessenger RNA accumulationInduced accumulationCell surfaceGranule accumulationProteinGrowth factor
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