Yiwei Xiong
Associate Research Scientist in Cell BiologyDownloadHi-Res Photo
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Cell Biology
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Associate Research Scientist in Cell Biology
Appointments
Cell Biology
Associate Research ScientistPrimary
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Education & Training
- PhD
- University of Liverpool, Institute of Integrative Biology
- MSc
- Sun Yat-sen University, Pharmaceutical Sciences
- BS
- Sun Yat-sen University, Pharmaceutical Sciences
Research
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Overview
Medical Research Interests
Immunotherapy; Signal Transduction
ORCID
0000-0002-6205-4691- View Lab Website
Xiaolei Su Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yiwei Xiong's published research.
Research Interests
Research topics Yiwei Xiong is interested in exploring.
Xiaolei Su, PhD
Kazuki Sato, PhD
Longhui Zeng, PhD
Maohan Su
Signal Transduction
Publications
2026
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine
Xiong Y, Tomares D, Guo J, Sato K, Zeng L, Tian Y, Su M, Albis A, Pant A, Pappu R, Su X. Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine. Nature Chemical Biology 2026, 1-12. PMID: 41760814, PMCID: PMC13010460, DOI: 10.1038/s41589-026-02165-6.Peer-Reviewed Original ResearchThis study investigates how mast cell extracellular granules form via interactions between heparin and polyamines, creating unique microenvironments that enhance immune mediator activity.
2025
783 Oncogenic PLCG1 drives aberrant intra- and intercellular T cell activation
Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Kogure Y, Kataoka K, Ogawa S, Sondek J, Su X. 783 Oncogenic PLCG1 drives aberrant intra- and intercellular T cell activation. 2025, a891-a891. DOI: 10.1136/jitc-2025-sitc2025.0783.Peer-Reviewed Original ResearchHyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance
Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Kogure Y, Kataoka K, Ogawa S, Sondek J, Su X. Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistance. EMBO Reports 2025, 26: 4563-4586. PMID: 40796680, PMCID: PMC12457681, DOI: 10.1038/s44319-025-00546-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPhospholipase C-gamma 1T cell activationDrug resistanceNon-canonical signalingBystander T cell activationCutaneous T-cell lymphomaC gamma 1Adult T-cell leukemia/lymphomaResistance to vorinostatPro-survival phenotypeAlpha-smooth muscle actinT-cell lymphomaT-cell leukemia/lymphomaT cell physiologyT cell proliferationSmooth muscle actinCritical functionT cell survivalT cell signalingLAT condensatesCell adhesion moleculesCell-autonomousERK activationMutated genesERK signaling
2023
The physical landscape of CAR-T synapse
Xiong Y, Libby K, Su X. The physical landscape of CAR-T synapse. Biophysical Journal 2023, 123: 2199-2210. PMID: 37715447, PMCID: PMC11331049, DOI: 10.1016/j.bpj.2023.09.004.Peer-Reviewed Original ResearchCitationsAltmetric
2022
ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia
Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cellular & Molecular Immunology 2022, 19: 898-912. PMID: 35637282, PMCID: PMC9149338, DOI: 10.1038/s41423-022-00881-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAdaptor proteinImmune thrombocytopeniaPharmacological inhibitionPlatelet phagocytosisTreatment of immune thrombocytopeniaInhibition of STAT1Etiology of immune thrombocytopeniaMacrophage phagocytosisSignal transducerDepletion of macrophagesModulation of signal transducerNuclear entryIntracellular immune checkpointSTAT1 SignalingSTAT1Immune checkpointsPhagocytosisIFN-gPlatelet clearanceSplenic macrophagesProinflammatory signalingThrombocytopeniaTherapeutic targetMacrophagesMice
2021
ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Yang N, Xiong Y, Wang Y, Yi Y, Zhu J, Ma F, Li J, Liu H. ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages. The Journal Of Immunology 2021, 206: 814-826. PMID: 33431658, DOI: 10.4049/jimmunol.2000569.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAdapter proteinSTAT3 activationCoactivator functionDegranulation-promoting adapter proteinActivation of STAT3Modulation of STAT3 activityADAP-deficient miceIL-6 stimulationT cell adhesionMouse macrophagesTyrosine phosphorylationAdaptor moleculeSTAT3 phosphorylationResponse to TLR4 activationSTAT3PhosphorylationTCR signalingTLR4-stimulated macrophagesInnate immune cellsCoactivatorTLR4 activationMacrophage plasticityStimulating effectExpression of proinflammatory cytokinesMotif
2020
T cell subset profile and inflammatory cytokine properties in the gut-associated lymphoid tissues of chickens during infectious bursal disease virus (IBDV) infection
Ruan Y, Wang Y, Guo Y, Xiong Y, Chen M, Zhao A, Liu H. T cell subset profile and inflammatory cytokine properties in the gut-associated lymphoid tissues of chickens during infectious bursal disease virus (IBDV) infection. Archives Of Virology 2020, 165: 2249-2258. PMID: 32696270, DOI: 10.1007/s00705-020-04735-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, CDB-Lymphocyte SubsetsBirnaviridae InfectionsBursa of FabriciusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChickensCTLA-4 AntigenGene Expression RegulationInfectious bursal disease virusInterferon-betaInterferon-gammaInterleukin-10Intestinal MucosaLymphocyte Activation Gene 3 ProteinPalatine TonsilPoultry DiseasesConceptsInfectious bursal disease virusInfectious bursal disease virus infectionBursa of FabriciusGut-associated lymphoid tissueCecal tonsilsT cell subsetsIBDV infectionDisease virusT cellsEffect of IBDV infectionIFN-gCytokine productionIL-10Lymphoid tissuePercentage of CD4+ T cellsCD8+ T cell subsetsLymphoid tissues of chickensT-cell subset profilesAvian gut-associated lymphoid tissueProportion of CD4+ cellsTissues of chickensCD4+ T cellsCTLA-4 mRNAT cell infiltrationCD4+ cells
2019
Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.
Xiong Y, Yi Y, Wang Y, Yang N, Rudd C, Liu H. Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells. The Journal Of Immunology 2019, 203: 3023-3036. PMID: 31666306, DOI: 10.4049/jimmunol.1900556.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsUbc9-mediated SUMOylationSLP-76Function of SLP-76IL-2 transcriptionTCR-proximal signaling eventsAdaptor SLP-76TCR signalingUbiquitin-like modifierProximal signaling eventsSH2 domainRegulatory complexControl of T cell activationSpanning residuesSUMOylationUbc9Signaling eventsT cell activationMouse T cellsTranscriptionTCR stimulationNFATT cellsTCRK266NFAT transcription
2018
STAU1 binds to IBDV genomic double‐stranded RNA and promotes viral replication via attenuation of MDA5‐dependent β interferon induction
Ye C, Yu Z, Xiong Y, Wang Y, Ruan Y, Guo Y, Chen M, Luan S, Zhang E, Liu H. STAU1 binds to IBDV genomic double‐stranded RNA and promotes viral replication via attenuation of MDA5‐dependent β interferon induction. The FASEB Journal 2018, 33: 286-300. PMID: 29979632, DOI: 10.1096/fj.201800062rr.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGenomic double-stranded RNADouble-stranded RNAInfectious bursal disease virusN-terminal moietyViral genomic double-stranded RNAAntiviral responseIBDV infectionIFN antiviral responseDsRNA in vitroMelanoma differentiation-associated protein 5Type I IFN antiviral responseRNA-binding protein Staufen1Overexpression of Staufen1Induction of type I IFNIFN-BViral replicationBinding regionIBDV replicationHost cellsGene transcriptionStaufen1Promoter activityType I IFNProtein 5Down-regulation
2017
Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion
Xiong Y, Ye C, Yang N, Li M, Liu H. Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion. The Journal Of Immunology 2017, 199: 4142-4154. PMID: 29127148, DOI: 10.4049/jimmunol.1700572.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsApoptosis Regulatory ProteinsCell AdhesionCell MembraneChlorocebus aethiopsCOS CellsEnzyme ActivationGene Knockdown TechniquesHumansIntegrinsJurkat CellsLymphocyte Function-Associated Antigen-1MiceModels, ImmunologicalMonomeric GTP-Binding ProteinsPhosphoproteinsPhosphorylationProtein BindingProtein Processing, Post-Translationalrac1 GTP-Binding Proteinrap1 GTP-Binding ProteinsReceptors, Antigen, T-CellRecombinant Fusion ProteinsRNA, Small InterferingSignal TransductionT-LymphocytesUbiquitin-Conjugating Enzyme UBC9Ubiquitin-Conjugating EnzymesConceptsIntegrin-mediated T cell adhesionT cell adhesionAdaptor proteinMembrane recruitmentRac1 activationMembrane targetingDegranulation-promoting adaptor proteinRap1-interacting adaptor moleculeIntegrin inside-out signalingInside-out signalingSmall GTPase Rap1Nuclear localization sequenceSmall GTPase Rac1Adhesion to ICAM-1LFA-1 clusteringKnockdown of UBC9GTPase Rac1Short hairpin RNAGTPase Rap1Integrin activationE2 conjugaseAdaptor moleculeLocalization sequenceUbc9IL-2 transcription
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