Yanis Chemli, PhD
Postdoctoral AssociateAbout
Research
Publications
2025
Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET
Zeng T, Najmaoui Y, Zhang J, Fontaine K, Hu Y, Chemli Y, Gallezot J, Sun C, Lu Y, Fakhri G, Carson R, Marin T. Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287015.Peer-Reviewed Original ResearchSpatially-varying point spread functionPoint spread functionAccurate point spread functionPSF modelConvergence behaviorImage qualityPoint spread function modelReconstruction toolboxPSF parametersHigh-activity regionsBrain-dedicated PET scannersDepth of interactionPoint-spread-function modelingField of viewSpatial resolutionHuman scansContrast recoverySpread functionPET systemPET scannerReal phantomBrain phantomMonte Carlo simulationsBrain positron emission tomographyCarlo simulationsPhysics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET
Chemli Y, Najmaoui Y, Normandin M, Fakhri G, Marin T, Ouyang J. Physics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287851.Peer-Reviewed Original ResearchDeep Image PriorList-modeContrast recoveryMotion correctionList-mode eventsReconstructed activity distributionHoffman brain phantomNoise-resolution trade-offML-EM reconstructionLow-count dataResolution phantomBrain phantomBrain positron emission tomographySuper-resolution effectActivity distributionModel attenuationML-EMBack-projection operationsFine structureDown-sampled dataNegative log-likelihoodImage registrationUnsupervised regularizerBack-projectionImage priorsO119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY.
Depauw N, Bijari F, Garonna A, Kang J, Chemli Y, Deng H, Dhaynaut M, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian M, Fakhri G, Levine R, Lehmann H, Chen Y, Jee K. O119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY. International Journal Of Particle Therapy 2025, 17: 100875. DOI: 10.1016/j.ijpt.2025.100875.Peer-Reviewed Original ResearchYRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER
Najmaoui Y, Fontaine K, Fontaine D, Zhang J, Zeng T, Volpi T, Chemli Y, Gallezot J, Tétrault M, Carson R, Fakhri G, Marin T. YRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER. 2025, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287275.Peer-Reviewed Original ResearchOpen-sourcePeak-to-valley ratioMini-Derenzo phantomReconstruction platformResolution PET scannerImage reconstruction toolsPacket decodingDetector geometryGPU accelerationMemory usagePET scannerPET systemAccurate system modelMotion correctionScatter estimationVendor softwareReconstruction timeImage reconstructionPluginImage qualitySoftwareHuman datasetsSystem modelManufacturing softwareNon-human primatesLR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization
Djebra Y, Najmaoui Y, Chemli Y, Normandin M, Fakhri G, Ma C, Marin T. LR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization. 2025, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57106.2025.11286709.Peer-Reviewed Original ResearchOn Hallucinations in Artificial Intelligence–Generated Content for Nuclear Medicine Imaging (the DREAM Report)
Xia M, Bayerlein R, Chemli Y, Liu X, Ouyang J, Lin M, Fakhri G, Badawi R, Li Q, Liu C. On Hallucinations in Artificial Intelligence–Generated Content for Nuclear Medicine Imaging (the DREAM Report). Journal Of Nuclear Medicine 2025, 67: 166-174. PMID: 41198241, PMCID: PMC12866389, DOI: 10.2967/jnumed.125.270653.Peer-Reviewed Original ResearchYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchOpen-sourceImage reconstructionPositron emission tomography image reconstructionReconstruction algorithmAdvanced image reconstruction algorithmsOpen-source toolkitDevelopment of advanced algorithmsTime-of-flightScanner geometryNovel reconstruction algorithmImage reconstruction algorithmMotion correctionReusable codeGPU accelerationTime-of-flight informationPython bindingsPlugin systemSoftware toolkitMeaningful imagesData formatsFast implementationRigid motion correctionAdvanced algorithmsPoint spread function modelProprietary softwareA Large Animal Study of a Novel Cardiac-Ultrasound Image Guidance for Cardio-Respiratory-Gated Radiation Ablation to Ventricular Tachycardia Targets Using Proton Therapy
Chen Y, Bijari F, Deng H, Depauw N, Garonna A, Kang J, Kim H, Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G, Jee K, Chemli Y. A Large Animal Study of a Novel Cardiac-Ultrasound Image Guidance for Cardio-Respiratory-Gated Radiation Ablation to Ventricular Tachycardia Targets Using Proton Therapy. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e632. DOI: 10.1016/j.ijrobp.2025.06.2930.Peer-Reviewed Original ResearchMembrane potential imagingRespiratory motionProton therapyDose drop-offDual gateExpert radiation oncologistsLayered repaintingScatter doseSafety of proton therapyAnimal studiesPotential imagesImaging biomarkersRadiation ablationMembrane potentialEffect of protonationSingle-gateImage guidance systemIACUC-approved protocolEarly effectsFunctional imaging biomarkersEarly radiation effectsNon-invasive optionOARsPTVGTVDeformable Image Registration for Assessing Time-Course Effect of Proton Beam in the Heart in the Presence of Large Anatomical Variations
Kim H, Bijari F, Kang J, Chemli Y, Depauw N, Garonna A, Moon S, Chen Y, Levine R, Lehmann H, Normandin M, Fakhri G, Bortfeld T, Jee K. Deformable Image Registration for Assessing Time-Course Effect of Proton Beam in the Heart in the Presence of Large Anatomical Variations. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: e57-e58. DOI: 10.1016/j.ijrobp.2025.06.3404.Peer-Reviewed Original ResearchDeformable image registrationDeformation vector fieldsDeformable image registration methodProton beam irradiationContour propagationDeformable image registration frameworkContrast-enhanced CT imagesPET-CT scanEffects of proton beamsEffective propagationBeam irradiationCardiac motion vector fieldImage registrationTime course effectsProton beamDIR methodsTime pointsLeft ventricleVector fieldsCT imagesResponse to therapyWeeks post-irradiationImage similarity metricsImaging time pointsInverse consistencyIn vivo 3D myocardial membrane potential mapping in humans using PET/MRI
Bijari F, Han P, Marin T, Lee W, Chemli Y, Gertsenshteyn I, Mounime I, Djebra Y, Chi D, Normandin M, Ma C, Fakhri G. In vivo 3D myocardial membrane potential mapping in humans using PET/MRI. EJNMMI Research 2025, 15: 93. PMID: 40715686, PMCID: PMC12297085, DOI: 10.1186/s13550-025-01287-7.Peer-Reviewed Original ResearchMembrane potentialExtracellular volume fraction measurementsExtracellular volume fraction mappingBolus-plus-infusion protocolT1 mapping sequencesVolume of distributionWritten Informed ConsentCardiac PET/MR imagingRigid image registrationHumans in vivoContrast agent injectionPET motion correctionFree breathingTracer volume of distributionImage registrationBolus injectionCardiac MRMitochondrial membrane potentialCardiac diseaseHealthy subjectsPET/MR imagingImaging studiesTreatment monitoringAgent injectionPET tracers