Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVivian Rotman
Assistant Professor AdjunctAbout
Research
Publications
2025
High frequency of ABCB4 and ABCB11 gene variants in adult patients with idiopathic chronic or recurrent cholestasis
Bittencourt P, Rotman V, Codes L, de Andrade A, de Araújo Gama R, Celestino L, Paraná R, Ferraz M, de Athayde Costa L, Thompson R, Porta G. High frequency of ABCB4 and ABCB11 gene variants in adult patients with idiopathic chronic or recurrent cholestasis. Hepatology Communications 2025, 10: e0851. PMCID: PMC12708102, DOI: 10.1097/hc9.0000000000000851.Peer-Reviewed Original ResearchClinical and Prognostic Factors Associated With Inflammatory Bowel Disease in a Highly Admixed Population With Primary Sclerosing Cholangitis.
Nardelli M, Cançado G, Barros L, Dotta D, Faria L, Rotman V, Villela-Nogueira C, Ferraz M, Rocco R, Felga G, Martins A, Codes L, Mendes L, Silva M, Hyppolito E, Gomide G, Signorelli I, Oliveira M, Ivantes C, Chiara M, Borges V, Terrabuio D, Cançado E, Bittencourt P, Couto C. Clinical and Prognostic Factors Associated With Inflammatory Bowel Disease in a Highly Admixed Population With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2025 PMID: 40985598, DOI: 10.1097/mcg.0000000000002253.Peer-Reviewed Original ResearchPrimary sclerosing cholangitisInflammatory bowel disease diagnosisInflammatory bowel diseaseTransplant-free survivalAdvanced liver diseaseLiver transplantationLiver diseasePSC patientsSclerosing cholangitisAntinuclear antibodiesCombined outcomeAssociation of inflammatory bowel diseaseCombined outcome of deathAnti-smooth muscle antibodiesConcomitant inflammatory bowel diseasePrevalence of inflammatory bowel diseasePSC diagnosisBowel diseaseCohort of Brazilian patientsStudy Group databaseOutcome of deathCohort mortalityMuscle antibodiesAutoimmune hepatitisBrazilian patientsAMA-NEGATIVE PRIMARY BILIARY CHOLANGITIS IN LATIN AMERICA: A DISTINCT SUBSET WITH LOWER TREATMENT RESPONSE
Couto C, Cançado G, Ferraz M, Terrabuio D, Villamil A, Solari L, Castro-Narro G, Ridruejo E, Villela-Nogueira C, Guerrero D, Chiodi D, Enrique C, Bittencourt P, Pereira G, Bessone F, Hernández S, Zapata R, Cheinquer H, López N, Mendizabal M, Mendes L, Murillo P, Narciso-Schiavon J, Faria L, Nardelli M, de Araújo Gama R, Amaral A, Pessoa M, Braga M, Cançado E, Andreina A, Sobenko N, Vuskovic F, Puentes G, Peralta M, Rodriguez H, Rotman V, Orozco F, Lynch R, Hernandez N. AMA-NEGATIVE PRIMARY BILIARY CHOLANGITIS IN LATIN AMERICA: A DISTINCT SUBSET WITH LOWER TREATMENT RESPONSE. Annals Of Hepatology 2025, 30: 102013. DOI: 10.1016/j.aohep.2025.102013.Peer-Reviewed Original ResearchPrimary biliary cholangitisAnti-mitochondrial antibodiesAnti-mitochondrial antibody statusAMA-negative PBCAMA-negative patientsUrsodeoxycholic acidBiliary cholangitisIncomplete response to UDCAPresence of anti-mitochondrial antibodiesResponse to UDCAResponse to ursodeoxycholic acidAMA-negative PBC patientsPrimary biliary cholangitis patientsEpidemiological profileTransplant-free survivalAMA-positive patientsRates of female sexInternational multicenter cohort studyMulticenter cohort studyAutoimmune cholestatic diseaseAMA-positiveBaseline cirrhosisFibrate therapyPBC patientsAMA-negativeFIBRATES SEEM TO BE EQUALLY EFFECTIVE AS SECOND-LINE THERAPY IN PRIMARY BILIARY CHOLANGITIS, WITH BIOCHEMICAL RESPONSE PLATEAUING AT 6 MONTHS
Cançado G, Ferraz M, Terrabuio D, Villamil A, Solari L, Castro-Narro G, Ridruejo E, Villela-Nogueira C, Fernandes M, Chiodi D, Enrique C, Bittencourt P, Pereira G, Bessone F, Cerda E, Zapata R, Cheinquer H, Urzúa Á, Mendizabal M, Mendes L, Murillo P, Narciso-Schiavon J, Gelape F, Santos V, de Araujo Gama R, Amaral A, Pessoa M, Rufino S, Cançado E, Fragens A, Sobenko N, Vuskovic F, Puentes G, Peralta M, Rodrigues H, Nogueira L, Rotman V, Orozco F, Hernandez N, Couto C. FIBRATES SEEM TO BE EQUALLY EFFECTIVE AS SECOND-LINE THERAPY IN PRIMARY BILIARY CHOLANGITIS, WITH BIOCHEMICAL RESPONSE PLATEAUING AT 6 MONTHS. Annals Of Hepatology 2025, 30: 102014. DOI: 10.1016/j.aohep.2025.102014.Peer-Reviewed Original ResearchPrimary biliary cholangitisSecond-line therapyPrimary biliary cholangitis patientsUrsodeoxycholic acidBiliary cholangitisBiochemical response to ursodeoxycholic acidResponse to ursodeoxycholic acidMulticenter cohort studyAssociated with cirrhosisLong-term outcomesPOISE criteriaToronto criteriaAbdominal painBiochemical outcomesFibrate useMedian timeLiver transplantationRenal injuryAdverse eventsOff-labelCohort studyDeep responsesLiver injuryIncomplete responsePatientsSAT-375 Frequency of ATP7B gene variants in brazilian patients with Wilson’s disease
Chindamo M, Schwartz I, Quintana G, Judice C, da Rocha B, Sgobbi P, Guaraná T, Rotman V, Agoglia L, Franz C, Perez R. SAT-375 Frequency of ATP7B gene variants in brazilian patients with Wilson’s disease. Journal Of Hepatology 2025, 82: s743. DOI: 10.1016/s0168-8278(25)01943-9.Peer-Reviewed Original Research
2024
P-80 RECURRENCE OF PRIMARY SCLEROSING CHOLANGITIS AFTER LIVER TRANSPLANTATION: RESULTS FROM THE BRAZILIAN CHOLESTASIS CONSORTIUM
Bittencourt P, Nardelli M, Barros L, Cançado G, Cançado E, Terrabuio D, Villela-Nogueira C, Ferraz M, Codes L, Rotman V, Rocco R, Felga G, Dotta D, de Souza Martins A, Mendes L, da Silva M, Hyppolito E, Gomide G, Signorelli I, de Oliveira M, Ivantes C, Chindamo M, de Almeida e Borges V, Faria L, Couto C. P-80 RECURRENCE OF PRIMARY SCLEROSING CHOLANGITIS AFTER LIVER TRANSPLANTATION: RESULTS FROM THE BRAZILIAN CHOLESTASIS CONSORTIUM. Annals Of Hepatology 2024, 29: 101694. DOI: 10.1016/j.aohep.2024.101694.Peer-Reviewed Original ResearchPrimary sclerosing cholangitisLiver transplantationSclerosing cholangitisRisk of disease recurrenceRecurrent primary sclerosing cholangitisDe novo inflammatory bowel diseaseStudy Group databaseInflammatory bowel diseaseStatistically significant associationPSC patientsDisease recurrenceAllograft rejectionMELD scoreFollow-upLatin patientsPrimary outcomeBowel diseaseRisk factorsCholangitisGroup databasePatientsSignificant associationRiskAgeAllograftP-9 SURVIVAL ANALYSIS OF A BRAZILIAN COHORT OF PATIENTS WITH WILSON DISEASE
Chindamo M, Rotman V, de Castro N, Canoilas D, Santos U, Evangelista A, Calçado F, Nabuco L, de Mello Perez R. P-9 SURVIVAL ANALYSIS OF A BRAZILIAN COHORT OF PATIENTS WITH WILSON DISEASE. Annals Of Hepatology 2024, 29: 101623. DOI: 10.1016/j.aohep.2024.101623.Peer-Reviewed Original ResearchLong-term survivalWD patientsWilson's diseaseNeuropsychiatric manifestationsRare autosomal recessive diseaseAverage survivalCohort of WD patientsAssociated with liver diseaseAutosomal recessive diseaseWorse survivalYounger patientsDisease durationBrazilian cohortHepatic manifestationSurvival curvesEarly diagnosisLiver diseaseRecessive diseaseCopper excretionSurvival ratePatientsNeuropsychiatric disordersMortality rateDiagnosisDisease phenotypeP-109 ALKALINE PHOSPHATASE AND CIRRHOSIS AT DIAGNOSIS ARE ASSOCIATED WITH DEEP RESPONSE TO URSODEOXYCHOLIC ACID IN PRIMARY BILIARY CHOLANGITIS
Cançado G, Fucuta P, de Faria Gomes N, Couto C, Cançado E, Terrabuio D, Villela-Nogueira C, Braga M, Nardelli M, Faria L, Oliveira E, Rotman V, Oliveira M, da Cunha S, DA SILVA M, Mendes L, Ivantes C, Codes L, de Almeida e Borges V, de Lima Pace F, Pessoa M, Signorelli I, Coral G, BITTENCOURT P, Ferraz M. P-109 ALKALINE PHOSPHATASE AND CIRRHOSIS AT DIAGNOSIS ARE ASSOCIATED WITH DEEP RESPONSE TO URSODEOXYCHOLIC ACID IN PRIMARY BILIARY CHOLANGITIS. Annals Of Hepatology 2024, 29: 101723. DOI: 10.1016/j.aohep.2024.101723.Peer-Reviewed Original ResearchUrsodeoxycholic acidDeep responsesNormalization of alkaline phosphataseProgressive autoimmune liver diseaseResponse to UDCA therapyYear of UDCA treatmentResponse to ursodeoxycholic acidBaseline alkaline phosphatase levelsPrimary biliary cholangitisAutoimmune liver diseaseStudy Group cohortAlkaline phosphatase levelsResponse scoresAlkaline phosphataseBaseline ALPToronto criteriaUDCA therapyUDCA treatmentPrognostic factorsBiliary cholangitisPrognostic markerPhosphatase levelsLiver diseaseIncomplete responseMultivariate modelP-83 REDUCTION OF LIVER STIFFNESS AFTER ANTICOPPER THERAPY IN WILSON'S DISEASE
Chindamo M, Rotman V, de Castro N, Canoilas D, Costa M, de Almeida M, Evangelista A, Santos U, Calçado F, Nabuco L, de Mello Perez R. P-83 REDUCTION OF LIVER STIFFNESS AFTER ANTICOPPER THERAPY IN WILSON'S DISEASE. Annals Of Hepatology 2024, 29: 101697. DOI: 10.1016/j.aohep.2024.101697.Peer-Reviewed Original ResearchPresentation of WDLiver stiffnessAnticopper therapyClinical presentationWilson's diseaseTransient hepatic elastographyDiagnosis of WDClinical follow-upClinical presentation of WDTreatment of patientsChronic liver diseaseFollow-up intervalHepatic elastographyHepatic elasticityIntrahepatic depositsLiver transplantationWD manifestationsFollow-upNeurological manifestationsLiver inflammationMedian reductionValue of LSHepatic manifestationChelation therapyLiver diseaseOP-16 FREQUENCY OF ATP7B GENE MUTATIONS IN A BRAZILIAN COHORT OF PATIENTS WITH WILSON'S DISEASE
Chindamo M, Judice C, Valladares M, da Rocha B, do Vale E, Pereira A, Santos U, Evangelista A, Calçado F, Rotman V, Nabuco L, de Mello Perez R. OP-16 FREQUENCY OF ATP7B GENE MUTATIONS IN A BRAZILIAN COHORT OF PATIENTS WITH WILSON'S DISEASE. Annals Of Hepatology 2024, 29: 101614. DOI: 10.1016/j.aohep.2024.101614.Peer-Reviewed Original ResearchDiagnosis of WDDisease phenotypeNeurological manifestationsT variantAssociated with disease phenotypesWilson's diseaseHighest allele frequencyExon 2 deletionAssociated with several neurological manifestationsFirst-degree relativesSevere neurological manifestationsATP7B mutationsAllele frequenciesCase of WDATP7B geneMutation c.Heterozygous relativesGenetic diseasesWD presentationMolecular analysisCompound heterozygosityNeurological phenotypeBrazilian cohortMutationsPhenotypic presentation