Susana Nakandakari, PhD
Postdoctoral AssociateCards
About
Research
Publications
2026
Changes in weight and metabolic health during and after cessation of a time-restricted feeding plus aerobic training in Swiss mice fed a high-fat diet
Fudoli Lins Vieira R, Castelo Branco Ramos Nakandakari S, Calheiros Antunes G, Azevedo Macedo A, Damasceno de Lima R, da Silva Rios T, Tobar N, Rosetto Muñoz V, Calais Gaspar R, da Silva A, Esper Cintra D, Rochete Ropelle E, Chaix A, Pauli J. Changes in weight and metabolic health during and after cessation of a time-restricted feeding plus aerobic training in Swiss mice fed a high-fat diet. AJP Endocrinology And Metabolism 2026, 330: e431-e441. PMID: 41670954, DOI: 10.1152/ajpendo.00432.2025.Peer-Reviewed Original ResearchConceptsTime-restricted feedingHigh-fat dietMetabolic healthSwiss miceLifestyle interventionFirst-line therapyIntervention cessationHigh-fat diet ad libitumDevelopment of obesityAdipose tissue hypertrophyDiet-induced obesityImpaired glycemic controlUnhealthy eating habitsSwiss male miceWeight gainLower body weightLong-term adherenceSignificant health problemAerobic trainingWeight regainMale miceTissue hypertrophyMetabolic parametersMetabolic improvementGlycemic control
2025
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition
Leitner B, Fosam A, Lee W, Zilinger K, Nakandakari S, Zhang X, Gaspar R, Zhu W, Perry C, Rabinowitz J, Perry R. Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2508707122. PMID: 41325517, PMCID: PMC12704748, DOI: 10.1073/pnas.2508707122.Peer-Reviewed Original ResearchConceptsExercise trainingExercise capacityAerobic exercise trainingRegular exercise trainingHigher exercise capacityMuscle glucose metabolismVoluntary wheel runningTumor progressionGlucose metabolismVoluntary exerciseCardiac muscleExerciseTumor glucose metabolismTumor-host interactionsMetabolic competitionStage of diseaseMuscleCancer prognosisSystemic glucose metabolismTumor energeticsTumor microenvironmentMelanoma tumorsTumor growthTumor developmentTrainingSupplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models
Castelo Branco Ramos Nakandakari S, Elliott E, Fudoli Lins Vieira R, da Silva Rios T, Fosam A, Betim Pavan I, Maftoum Costa M, Salvino da Silva L, de Oliveira Ramos C, Rios Gonçalves G, Akingbesote N, Sidarta-Oliveira D, Moreli A, Rosseto Braga R, Pinto A, Eisenstein A, Velloso L, Simabuco F, Pauli J, Rochete Ropelle E, Ramos da Silva A, Wang A, Perry R, Cintra D. Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models. AJP Endocrinology And Metabolism 2025, 329: e663-e675. PMID: 40938960, PMCID: PMC13035247, DOI: 10.1152/ajpendo.00147.2025.Peer-Reviewed Original ResearchOmega-3 supplementationAnti-inflammatory propertiesSepsis survivalOmega-3Impact of omega-3 supplementationGPR120 mRNA expressionSecondary to infectionMurine sepsis modelActivation of GPR120Prevention of cardiovascular diseaseLevels of inflammationImpact of omega-3Omega-3 fatty acidsAnti-inflammatory functionsOrgan dysfunctionCecal ligationInflammatory markersBone marrowImmune cellsPreclinical studiesC57BL/6J miceCLP modelLipopolysaccharide administrationSepsis modelClinical studiesA comprehensive model of blood flow restriction in the postsurgical rat
Fosam A, Nakandakari S, Miranda I, Taber C, O'Connell J, Raines A, Ohashi Y, Bai H, Dardik A, Allen C, Perry R. A comprehensive model of blood flow restriction in the postsurgical rat. Physiological Reports 2025, 13: e70495. PMCID: PMC12325096, DOI: 10.14814/phy2.70495.Peer-Reviewed Original ResearchBlood flow restrictionBFR exerciseFlow restrictionKnee extension exerciseExtension exerciseAnterior cruciate ligament reconstructionBilateral anterior cruciate ligament reconstructionsCruciate ligament reconstructionClinically relevant protocolBlood flow occlusionMuscle hypertrophyMale ratsLigament reconstructionFlow occlusionPhysiological studiesRatsNotch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice
Gaspar R, Macêdo A, Nakandakari S, Muñoz V, Abud G, Vieira R, de Sousa Neto I, Pavan I, da Silva L, Simabuco F, da Silva A, Salgado W, Marchini J, Nonino C, Cintra D, Ropelle E, Pajvani U, de Freitas E, Pauli J. Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice. Liver International 2025, 45: e70068. PMID: 40078075, DOI: 10.1111/liv.70068.Peer-Reviewed Original ResearchConceptsNotch1 signalingAerobic exerciseRegulation of hepatic glucoseObese miceImpact of aerobic exerciseEffects of Notch1 signalingAerobic exercise trainingMTORC1 pathway activationNotch1 pathwayObese individualsTissue of obese miceCross-sectional studyNotch1 mRNA levelsMitochondrial respirationExercise trainingLivers of obese individualsTreadmill runningGluconeogenic enzymesHepG2 cell lineLipid accumulationTraining groupHepatic glucoseHepatic metabolismNotch1 proteinPathway activationThe other side of the incretin story: GIPR signaling in energy homeostasis
Nakandakari S, Fosam A, Perry R. The other side of the incretin story: GIPR signaling in energy homeostasis. Cell Metabolism 2025, 37: 1-3. PMID: 39778517, DOI: 10.1016/j.cmet.2024.12.003.Peer-Reviewed Original Research
2024
The Effects of High‐Fat Diet and Flaxseed Oil‐Enriched Diet on the Lung Parenchyma of Obese Mice
de Oliveira Ramos C, Sant'Ana M, Gonçalves G, da Silva Rios T, Nakandakari S, Burger B, Fernandes L, de Lima Zollner R, de Oliveira A, Ramos R, da Silva A, Pauli J, de Moura L, Ropelle E, Mansour E, Cintra D. The Effects of High‐Fat Diet and Flaxseed Oil‐Enriched Diet on the Lung Parenchyma of Obese Mice. Molecular Nutrition & Food Research 2024, 68: e2300050. PMID: 39205544, DOI: 10.1002/mnfr.202300050.Peer-Reviewed Original ResearchConceptsFlaxseed oilHigh-fat dietFatty acid profileLung parenchymaOil-enriched dietA-linolenicAcid profileEffect of flaxseed oilObese miceLungs of obese miceDevelopment of pulmonary complicationsPulmonary inflammatory responseControl groupWeight gainAnti-inflammatory potentialEffects of high-fat dietAnti-inflammatory cytokinesFood sourcesFatty acidsIndiscriminate useDietOmega-3Pulmonary complicationsFlaxseed oil-enriched dietCell infiltration
2023
Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet
Damasceno de Lima R, Fudoli Lins Vieira R, Rosetto Muñoz V, Chaix A, Azevedo Macedo A, Calheiros Antunes G, Felonato M, Rosseto Braga R, Castelo Branco Ramos Nakandakari S, Calais Gaspar R, Ramos da Silva A, Esper Cintra D, Pereira de Moura L, Mekary R, Rochete Ropelle E, Pauli J. Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet. AJP Endocrinology And Metabolism 2023, 325: e513-e528. PMID: 37755454, PMCID: PMC10864020, DOI: 10.1152/ajpendo.00129.2023.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseResistance exercise trainingTime-restricted feedingFatty liver diseaseHigh-fat dietLiver diseaseExercise trainingWeight gainGlycemic homeostasisMetabolic disordersEffects of TRFCommon liver diseaseDiet-induced obesityMajor risk factorEnergy expenditureFatty acid oxidation genesLiver of miceAccumulation of fatBody weight gainRespiratory exchange rateAccumulation of lipidsLower mRNA expressionRT groupPrevents obesityRisk factorsThe early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions
Rodrigues P, Dátilo M, Sant'Ana M, Nogueira G, Marin R, Nakandakari S, de Moura L, da Silva A, Ropelle E, Pauli J, Cintra D. The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions. The Journal Of Nutritional Biochemistry 2023, 119: 109410. PMID: 37364793, DOI: 10.1016/j.jnutbio.2023.109410.Peer-Reviewed Original ResearchConceptsFlaxseed oilTight junctionsHigh-fat dietCT groupHigh-fat (HF) dietChow dietIL1B transcriptionEpididymal fat depotsUnsaturated fatty acidsHuman databaseGut alterationsGut permeabilityCD11b proteinFatty acidsFS dietGutIleum inflammationIntestinal inflammationInflammatory parametersImpact of dietBody weight massMale miceObesity developmentFatty dietFat depotsEffects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice
Muñoz V, Botezelli J, Gaspar R, da Rocha A, Vieira R, Crisol B, Braga R, Severino M, Nakandakari S, Antunes G, Brunetto S, Ramos C, Velloso L, Simabuco F, de Moura L, da Silva A, Ropelle E, Cintra D, Pauli J. Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice. Cellular And Molecular Life Sciences 2023, 80: 122. PMID: 37052684, PMCID: PMC11072257, DOI: 10.1007/s00018-023-04771-2.Peer-Reviewed Original ResearchConceptsWhole-body glucose homeostasisSkeletal muscle glucose uptakeMuscle glucose uptakeMitochondrial adaptationsMitochondrial activityPost-translational mechanismsSkeletal muscleGlucose uptakeC2C12 cell lineInsulin resistanceStrength exercisesGlucose homeostasisMouse modelPhysical exerciseProtein response markersShort-term physical activityMolecular regulationTranscriptomic modulationRNA sequencingImpact of hyperglycemiaC2C12 cellsStrength exercise trainingType 2 diabetesStrength training protocolsMitochondrial function
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