Richard Bungiro, BA, PhD
Research Scientist in Epidemiology (Microbial Diseases)Cards
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Titles
Research Scientist in Epidemiology (Microbial Diseases)
Appointments
Epidemiology of Microbial Diseases
Research ScientistPrimary
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Education & Training
- PhD
- Brown University, Pathobiology
- BA
- The Johns Hopkins University, Biology
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Richard Bungiro's published research.
Publications Timeline
A big-picture view of Richard Bungiro's research output by year.
Michael Cappello, MD
Debbie Humphries, PhD, MPH, MA
21Publications
798Citations
Publications
2022
Comparison of percutaneous vs oral infection of hamsters with the hookworm Ancylostoma ceylanicum: Parasite development, pathology and primary immune response
Bungiro RD, Harrison LM, Dondji B, Cappello M. Comparison of percutaneous vs oral infection of hamsters with the hookworm Ancylostoma ceylanicum: Parasite development, pathology and primary immune response. PLOS Neglected Tropical Diseases 2022, 16: e0010098. PMID: 34986139, PMCID: PMC8765627, DOI: 10.1371/journal.pntd.0010098.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCellular immune responsesGolden Syrian hamstersImmune responsePercutaneous infectionOral infectionSyrian hamstersAncylostoma ceylanicumPrimary immune responseRoute of infectionModerate growth delayFaecal egg outputPercutaneous groupImmunological manifestationsAntibody titersHookworm Ancylostoma ceylanicumInfected hamstersWorm recoveryLarval antigensBlood hemoglobinDisease pathogenesisHost responseGrowth delayHuman infectionsInfectionA. ceylanicum
2011
In Response
Humphries D, Mosites E, Otchere J, Bungiro R, Jones-Sanpei H, Harrison L, Wilson M, Cappello M. In Response. American Journal Of Tropical Medicine And Hygiene 2011, 85: 581-581. PMCID: PMC3163889, DOI: 10.4269/ajtmh.2011.11-0317b.Peer-Reviewed Original ResearchEpidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Humphries D, Mosites E, Otchere J, Twum WA, Woo L, Jones-Sanpei H, Harrison LM, Bungiro RD, Benham-Pyle B, Bimi L, Edoh D, Bosompem K, Wilson M, Cappello M. Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure. American Journal Of Tropical Medicine And Hygiene 2011, 84: 792-800. PMID: 21540391, PMCID: PMC3083749, DOI: 10.4269/ajtmh.2011.11-0003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPoor nutritional statusHookworm infectionRisk factorsNutritional statusOverall egg reduction rateSerum immunoglobulin G (IgG) reactivitiesCross-sectional pilot studyEgg reduction rateImmunoglobulin G reactivityKintampo North MunicipalityAlbendazole therapyKintampo NorthMalaria coinfectionTreatment failureOverall prevalenceHigh prevalenceRepeat examinationEgg excretionSecretory antigensInfectionPilot studyCoinfectionSignificant reductionTherapyHigh rateTwenty-First Century Progress Toward the Global Control of Human Hookworm Infection
Bungiro R, Cappello M. Twenty-First Century Progress Toward the Global Control of Human Hookworm Infection. Current Infectious Disease Reports 2011, 13: 210-217. PMID: 21462001, DOI: 10.1007/s11908-011-0182-z.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHuman hookworm infectionHost immune responseCandidate vaccine antigensHigher infection rateExcretory/secretory proteinsImmunoepidemiological studiesTreatment failureHookworm infectionMass chemotherapyImmune responseAnimal modelsParasitic infectionsVaccine antigensMolecular pathogenesisInfection rateHookworm diseaseReduced efficacyProtease inhibitorsHookwormInfectionSaharan AfricaRecent studiesContinued useSecretory proteinsAsthma
2010
CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection
DONDJI B, SUN T, BUNGIRO RD, VERMEIRE JJ, HARRISON LM, BIFULCO C, CAPPELLO M. CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection. Parasite Immunology 2010, 32: 406-413. PMID: 20500671, PMCID: PMC3241967, DOI: 10.1111/j.1365-3024.2010.01204.x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsT cellsImmune responseHookworm infectionHost cellular immune responseExperimental hookworm infectionT-cell depletionMesenteric lymph nodesSystemic immune responsesCellular immune responsesHumoral immune responseIntestinal nematode infectionsIntestinal worm burdenResource-limited countriesHookworm antigensLymph nodesSevere anemiaIntraperitoneal injectionLymphocyte proliferationHookworm Ancylostoma ceylanicumIsotype controlDisease pathogenesisWorm burdenSyrian hamstersAncylostoma ceylanicumEffector role
2009
Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum
Fairfax KC, Vermeire JJ, Harrison LM, Bungiro RD, Grant W, Husain SZ, Cappello M. Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum. International Journal For Parasitology 2009, 39: 1561-1571. PMID: 19591834, PMCID: PMC2760681, DOI: 10.1016/j.ijpara.2009.06.005.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMucosal adjuvant cholera toxinAdjuvant cholera toxinCause of anemiaLive adult wormsIntestinal worm burdenFatty acidsResource limited countriesFatty acid uptakeHookworm Ancylostoma ceylanicumReal-time PCRFatty acids de novoWorm burdenVaccine developmentLimited countriesIntestinal nematodesEx vivoA. ceylanicumCholera toxinHookworm biologyIndividual fatty acidsAncylostoma ceylanicumAcid uptakeAdult wormsProtein 1Potential role
2008
Mucosal antibody responses in experimental hookworm infection
BUNGIRO RD, SUN T, HARRISON LM, SHOEMAKER CB, CAPPELLO M. Mucosal antibody responses in experimental hookworm infection. Parasite Immunology 2008, 30: 293-303. PMID: 18312503, DOI: 10.1111/j.1365-3024.2008.01023.x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMucosal IgA responsesSystemic immune responsesIgA responsesImmune responseHookworm infectionInfected hamstersRobust systemic immune responseAncylostoma ceylanicum infectionExperimental hookworm infectionFecal IgA responsesParasite-specific IgAMucosal immune responsesMucosal antibody responsesIntestinal worm burdenExcretory-secretory productsMucosal antibodiesProtective immunityChallenge infectionSerum IgGAntibody responsePrimary infectionSecretory IgAHamster modelIntestinal mucosaWorm burdenRole for Nitric Oxide in Hookworm-Associated Immune Suppression
Dondji B, Bungiro RD, Harrison LM, Vermeire JJ, Bifulco C, McMahon-Pratt D, Cappello M. Role for Nitric Oxide in Hookworm-Associated Immune Suppression. Infection And Immunity 2008, 76: 2560-2567. PMID: 18347036, PMCID: PMC2423093, DOI: 10.1128/iai.00094-08.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntigen-presenting cellsHookworm infectionNitric oxideInfected animalsMesenteric lymph node cellsHost cellular immune responseCellular immune responsesLymph node cellsProliferative capacityT cell preparationsSurface immunoglobulin GParasite-induced immunosuppressionResource-poor countriesHookworm antigensMLN cellsLymphocyte subpopulationsPositive lymphocytesCellular immunityImmune suppressionLymphocyte proliferationNode cellsFluorescence-activated cell sortingInfected hamstersImmune responseAnimal studies
2007
Short report: an agar plate method for culturing hookworm larvae: analysis of growth kinetics and infectivity compared with standard coproculture techniques.
Reiss D, Harrison LM, Bungiro R, Cappello M. Short report: an agar plate method for culturing hookworm larvae: analysis of growth kinetics and infectivity compared with standard coproculture techniques. American Journal Of Tropical Medicine And Hygiene 2007, 77: 1087-90. PMID: 18165527, DOI: 10.4269/ajtmh.2007.77.1087.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
2006
A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum
Cappello M, Bungiro RD, Harrison LM, Bischof LJ, Griffitts JS, Barrows BD, Aroian RV. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 15154-15159. PMID: 17005719, PMCID: PMC1622792, DOI: 10.1073/pnas.0607002103.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCry proteinsCrystal proteinsSoil bacterium Bacillus thuringiensisBacterium Bacillus thuringiensisBacillus thuringiensis crystal proteinsBt Cry proteinsVivo anthelminthic activityFree-living nematodesA. ceylanicumLarval development assaysAdult A. ceylanicumGastrointestinal nematodesBacillus thuringiensisParasitic nematodesNematode parasitesVeterinary useCry5BAncylostoma ceylanicumNematodesDevelopment assaysEgg excretionAdult female wormsHuman diseasesWorm burdenPermissive host
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