Reza Aalizadeh
Associate Research Scientist in EpidemiologyCards
About
Research
Publications
2026
Glutathione-deficiency promotes basal hyperinsulinemia in the insulin secreting cell line INS-1 (832/13)
Davidson E, Chen Y, Cardone R, Thompson B, Aalizadeh R, Charkoftaki G, Kibbey R, Vasiliou V. Glutathione-deficiency promotes basal hyperinsulinemia in the insulin secreting cell line INS-1 (832/13). Chemico-Biological Interactions 2026, 433: 112080. PMID: 41962617, DOI: 10.1016/j.cbi.2026.112080.Peer-Reviewed Original ResearchINS-1 cellsTreatment of INS-1 cellsCellular redox stateINS-1Glutamate-cysteine ligase catalytic subunitInsulin-secreting cell line INS-1Cell line INS-1Cell functionRedox stateGSH synthesisCulture mediumIntracellular redox homeostasisInsulin secretionExcessive reactive oxygen speciesCatalytic subunitReactive oxygen speciesBasal hyperinsulinemiaScavenge excessive reactive oxygen speciesRedox homeostasisType 2 diabetesButhionine sulfoximineBasal insulin secretionGSH deficiencyGSH poolGSH/GSSG redox coupleIn-Depth Analysis of the Data from an Interlaboratory Study of Quantitative Non-Target Screening—How Do the Instrumental Methods Compare?
Malm L, Alygizakis N, Aalizadeh R, Kruve A. In-Depth Analysis of the Data from an Interlaboratory Study of Quantitative Non-Target Screening—How Do the Instrumental Methods Compare? Molecules 2026, 31: 875. PMID: 41828862, PMCID: PMC12986245, DOI: 10.3390/molecules31050875.Peer-Reviewed Original ResearchLiquid chromatography-high resolution mass spectrometryNon-target screeningOrganic modifierIonization efficiencyMass spectrometryInstrumental parametersCompoundsIonizationEnvironmental monitoringInstrumental methodsResponse factorInterlaboratory studyEfficient approachMonitoring of contaminantsSpectrometryQuantification approachStandard-based approachInterlaboratory comparisonExploring the chemical profile of Greek honey varieties via Liquid Chromatography coupled to Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry: from metabolomic fingerprint to varietal discrimination
Gialouris P, Nastou E, Preza-Mayo-Kataki D, Aalizadeh R, Dasenaki M, Thomaidis N. Exploring the chemical profile of Greek honey varieties via Liquid Chromatography coupled to Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry: from metabolomic fingerprint to varietal discrimination. Food Chemistry 2026, 504: 147855. PMID: 41610478, DOI: 10.1016/j.foodchem.2026.147855.Peer-Reviewed Original ResearchTrapped ion mobility spectrometryHigh-resolution mass spectrometryIon mobility spectrometryMobility spectrometryMass spectrometryMetabolomic fingerprintMetabolome compositionSpectrometryChemical profilesLiquid chromatographyGreek honeyAuthenticity markersQuantitative chemical characterizationCompoundsMethyl syringateSemi-quantitative modelVarietal discriminationChemical characterizationChemical compositionTest setComprehensive investigationBotanical originMethylationDehydrovomifoliolChromatography
2025
By integrating previously overlooked drivers AI boosts bioaccumulation assessment in fish
Köhler H, Aalizadeh R, Treu G, Gräff T, Peschke K, Prutz I, Thomaidis N, Triebskorn R, von der Ohe P. By integrating previously overlooked drivers AI boosts bioaccumulation assessment in fish. Journal Of Hazardous Materials 2025, 501: 140648. PMID: 41349307, DOI: 10.1016/j.jhazmat.2025.140648.Peer-Reviewed Original ResearchInvestigating the role of biotransformation in the toxicokinetics of ionizable organic compounds, using LC-HRMS: Zebrafish (Danio rerio) embryos exposed to ibuprofen as a case study
Panagopoulou E, Aleiferi E, Damalas D, Tzepkinli V, Kundy L, Schweizer M, Köhler H, Aalizadeh R, von der Ohe P, Triebskorn R, Thomaidis N. Investigating the role of biotransformation in the toxicokinetics of ionizable organic compounds, using LC-HRMS: Zebrafish (Danio rerio) embryos exposed to ibuprofen as a case study. Environment International 2025, 206: 109933. PMID: 41270662, DOI: 10.1016/j.envint.2025.109933.Peer-Reviewed Original ResearchConceptsIonizable organic compoundsBiotransformation of ibuprofenPH-dependent toxicityBioconcentration factorNon-target screening workflowInternal concentrationQuadrupole-time-of-flight mass spectrometryLiquid chromatography quadrupole-time-of-flight mass spectrometryToxicity of ibuprofenOrganic compoundsConcentrations of ibuprofenLC-QTOF-MSDanio rerioEffect of pHInterpretation of toxicityAquatic organismsAquatic ecosystemsLowest LC50 value ofChemical speciationNeutral speciesScreening workflowEnvironmental impactLC-HRMSMass spectrometryBiotransformation productsInvestigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging
Nikolopoulou V, Stem A, Vasiliou V, Aalizadeh R. Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging. Journal Of The American Society For Mass Spectrometry 2025, 36: 2460-2469. PMID: 41147643, DOI: 10.1021/jasms.5c00211.Peer-Reviewed Original ResearchConceptsIonization efficiencyAmmonium fluoridePresence of ammonium fluorideMass spectrometry imagingSmall moleculesIsotopically labeled metabolitesNegative polarity modeAnalysis of analytesEndogenous compoundsChemical structureIntermediate productsIonizationCompoundsMoleculesRelationship modelFluorideMALDIMetabolitesAnalytesComatrixQuantitationMatrixPolarization modesStructureDihydrochlorideOlive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. PMID: 41048290, PMCID: PMC12491241, DOI: 10.3389/fpubh.2025.1658525.Peer-Reviewed Original ResearchOlive treesEnvironmental impactHuman healthOlive by-productsClimate change mitigationHealth benefitsSustainable agricultural practicesHuman health benefitsMonounsaturated fatty acidsOlive sectorGreenhouse gas emissionsBiodiversity supportEcosystem stewardshipBy-productsFeed additivesOlive oil cultivationAnimal nutritionCarbon sequestrationSoil conservationOlive oil productionSustainable agricultureFood productsLivestock healthAntioxidant propertiesEcological sustainability
2024
From Chemical Similarity to Ionization Efficiency and Beyond: Toward Semi-Quantitative Analysis of Small Molecules and Its Integration in Non-targeted Screening
Nikolopoulou V, Thomaidis N, Aalizadeh R. From Chemical Similarity to Ionization Efficiency and Beyond: Toward Semi-Quantitative Analysis of Small Molecules and Its Integration in Non-targeted Screening. The Handbook Of Environmental Chemistry 2024, 138: 195-232. DOI: 10.1007/698_2024_1188.Peer-Reviewed Original ResearchNon-target screeningIonization efficiencyAnalysis of small moleculesCo-eluting analytesChemical structure similarityIonization sourceChemical derivatizationEnvironmental samplesSemi-quantitative analysisParent compoundSmall moleculesIonizationTransformation productsChemical similarityProperty similarityChemicalAnalytical methodDerivatizationStructural similarityCompoundsEnvironmental fateMoleculesAnalytesRisk assessment of chemicalsRisk assessmentQuantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison
Malm L, Liigand J, Aalizadeh R, Alygizakis N, Ng K, Fro̷kjær E, Nanusha M, Hansen M, Plassmann M, Bieber S, Letzel T, Balest L, Abis P, Mazzetti M, Kasprzyk-Hordern B, Ceolotto N, Kumari S, Hann S, Kochmann S, Steininger-Mairinger T, Soulier C, Mascolo G, Murgolo S, Garcia-Vara M, de Alda M, Hollender J, Arturi K, Coppola G, Peruzzo M, Joerss H, van der Neut-Marchand C, Pieke E, Gago-Ferrero P, Gil-Solsona R, Licul-Kucera V, Roscioli C, Valsecchi S, Luckute A, Christensen J, Tisler S, Vughs D, Meekel N, Andújar B, Aurich D, Schymanski E, Frigerio G, Macherius A, Kunkel U, Bader T, Rostkowski P, Gundersen H, Valdecanas B, Davis W, Schulze B, Kaserzon S, Pijnappels M, Esperanza M, Fildier A, Vulliet E, Wiest L, Covaci A, Schönleben A, Belova L, Celma A, Bijlsma L, Caupos E, Mebold E, Le Roux J, Troia E, de Rijke E, Helmus R, Leroy G, Haelewyck N, Chrastina D, Verwoert M, Thomaidis N, Kruve A. Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison. Analytical Chemistry 2024, 96: 16215-16226. PMID: 39353203, PMCID: PMC11483430, DOI: 10.1021/acs.analchem.4c02902.Peer-Reviewed Original ResearchNontarget screeningIonization efficiencyIonization efficiencies of compoundsElectrospray ionization high-resolution mass spectrometryHigh-resolution mass spectrometryNontargeted screening methodEfficiency of compoundsChemical coverageHPLC-grade waterAuthentic standardsMass spectrometryWater matricesSpiked concentrationsNORMAN networkQuantification approachCompoundsDiverse data setsIonizationStandard quantificationConcentration levelsLC/ESI/HRMSESI/HRMSGrade waterQuantificationEnvironmental contaminationCYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studies
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New Haven, CT 06510