Poojith Nuthalapati
Postdoctoral AssociateAbout
Research
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Featured Publications
Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population
Nuthalapati P, DeBonis D, Gopaul M, Okafor C, Orner M, Jimenez A, Altalib H. Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population. Epilepsy & Behavior 2025, 172: 110557. PMID: 40570732, DOI: 10.1016/j.yebeh.2025.110557.Peer-Reviewed Original ResearchVeteran populationRetrospective analysis of veteransPopulation of veteransAnalysis of veteransICD-10 codesPsychiatric adverse effectsAnti-seizure medicinesVA systemICD-10Neurology noteMale participantsVeteransCognitive adverse effectsSafety analyticsIntegrated programCognitive disordersAdverse effectsORQ1-Q3Treatment initiationChronic neurological disorderExercise cautionEffects of brivaracetamPopulationMedian ageInterventional Brain Medicine: Medicine's newest frontier
Nuthalapati P, Palmer C, Barbosa D, George M, Brown J. Interventional Brain Medicine: Medicine's newest frontier. Brain Medicine 2024, 1: 3-5. DOI: 10.61373/bm024g.0013.Commentaries, Editorials and LettersImproving Seizure Frequency Documentation and Classification
Nuthalapati P, Thomas L, Donahue M, Moura L, DeStefano S, Simpson J, Buchhalter J, Fureman B, Pellinen J. Improving Seizure Frequency Documentation and Classification. Neurology Clinical Practice 2023, 13: e200212. PMID: 37873534, PMCID: PMC10586801, DOI: 10.1212/cpj.0000000000200212.Peer-Reviewed Original ResearchElectronic health recordsEpilepsy Learning Healthcare SystemClinic visitsLearning healthcare systemQuality of careBaseline dataQuality improvement projectBaseline data collectionEpilepsy clinicHealth recordsCase report formsDocumentation habitsImprovement projectHealthcare systemDocumentation toolsReport formsVisitsEvaluate treatment strategiesClinicData collectionSeizure documentationBaselineSeizure frequencyCritical metricsCareAn analysis of structural, spectroscopic, quantum chemical and in silico studies of ethyl 3-[(pyridin-2-yl)amino]propanoate: A potential thrombin inhibitor
Poojith N, Rani N, Potla K, Rose J, Suchetan P, Pillai R, Vankayalapati S. An analysis of structural, spectroscopic, quantum chemical and in silico studies of ethyl 3-[(pyridin-2-yl)amino]propanoate: A potential thrombin inhibitor. Journal Of Molecular Structure 2021, 1226: 129378. DOI: 10.1016/j.molstruc.2020.129378.Peer-Reviewed Original ResearchBond dissociation energiesTitle compoundDissociation energiesSingle-crystal X-ray diffraction techniquesCrystal structureHydrogen-bond dissociation energiesNatural bond orbital analysisMolecular electrostatic surface potentialIn silico studiesOrbital energy calculationsPotential thrombin inhibitorsBond orbital analysisChemical reactivity descriptorsElectron density surfaceQuantum chemical calculationsVibrational wave numbersX-ray diffraction techniqueMolecular docking studiesExperimental spectral dataC-H.Fukui functionsReactivity descriptorsChemical calculationsQuantum chemicalOrbital analysisStructural, spectroscopic, and in silico studies of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol: A potential antidepressant agent
Poojith N, Kigga M, Rose J, Potla K, Vankayalapati S, Chinnam S, Adimoole S, Pillai R. Structural, spectroscopic, and in silico studies of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol: A potential antidepressant agent. Journal Of Molecular Structure 2022, 1250: 131859. DOI: 10.1016/j.molstruc.2021.131859.Peer-Reviewed Original ResearchMolecular electrostatic potentialPotential energy distributionDissociation energiesReactivity parametersCrystal X-ray diffractionSide chainsOrthorhombic P212121 space groupIn silico studiesLocal reactivity propertiesGlobal reactivity parametersN hydrogen bondsC(6) chainsMolecular orbital analysisP212121 space groupX-ray diffractionEnergy of hydrogenTitle compoundVibrational wavenumbersFukui functionsStaggered conformationThiophene ringCompound crystallizesOrbital analysisDihedral angleMethine carbon
2026
Burden of Headache Among People with Epilepsy: A Systematic Review and Meta-Analysis
Sharma A, Paruchuri A, Kola P, Nimisha P, Pal A, Agarwal H, Tiwari H, Nuthalapati P, Beriwal N, Kansal B, Garg R, Malhotra H, Singh A, Singh M, Suresh V. Burden of Headache Among People with Epilepsy: A Systematic Review and Meta-Analysis. Seizure 2026 DOI: 10.1016/j.seizure.2026.02.015.Peer-Reviewed Original ResearchBurden of headacheRandom-effects meta-analysesHeadache prevalencePooled prevalence of headachePooled prevalencePublication biasSystematic reviewRandom-effects meta-analyses of proportionsMeta-analysisPrevalence of headacheMeta-analyses of proportionsWeb of ScienceLFK indexEpilepsy careBackground HeadachePrevalence estimatesHeadache assessmentInterictal headacheHeadache subtypesFrequent subtypePostictal headachesSubgroup analysisUnderrecognized burdenCortical hyperexcitabilityObservational studyCenobamate beyond Epilepsy: exploring associations with vascular risk factors through serological markers
Jimenez A, Zhou X, Agadzhanian N, Hanin A, Toghramadjian I, Okafor C, Nuthalapati P, Tallapalli J, Sakya S, Singh A, Altalib H, Mattson R, Schoenfeld M, Herlopian A. Cenobamate beyond Epilepsy: exploring associations with vascular risk factors through serological markers. Epilepsy & Behavior 2026, 176: 110890. PMID: 41616663, DOI: 10.1016/j.yebeh.2026.110890.Peer-Reviewed Original ResearchInternational normalized ratioAnti-seizure medicationsTotal cholesterolLDL-CHDL-CRetrospective analysisLipoprotein cholesterolVascular effectsDiabetes mellitusRisk factorsLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolRetrospective analysis of adultsDefinitive evaluationLipid profile changesEnzyme-inducing agentsDose-dependent changesDose-dependent effectCerebrovascular risk factorsAnalysis of adultsStatin useAnticoagulant useMulticenter studyRetrospective studyVascular risk factors
2025
Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights
Nuthalapati P, Holmes S, Altalib H, Fesharaki-Zadeh A. Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights. International Journal Of Molecular Sciences 2025, 26: 9604. PMID: 41096867, PMCID: PMC12525020, DOI: 10.3390/ijms26199604.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTraumatic brain injuryChronic phaseImpact of traumatic brain injuryBrain injuryDendritic spinesImpaired synaptic plasticityLong-term impacts of TBIAcute phaseLoss of dendritic spinesSynaptic dysfunctionPhase of traumatic brain injuryGABAergic disruptionMemory deficitsNeurotransmitter systemsAcute phase of traumatic brain injuryDevelopment of post-traumatic epilepsyMood disturbancePost-TBISynaptic plasticityPost-traumatic epilepsyNeurological sequelaeExcitotoxic injurySynaptic densitySynaptic pathologyCerebral edemaInfluence of Exercise on Oxygen Consumption, Pulmonary Ventilation, and Blood Gas Analyses in Individuals with Chronic Diseases
Korivi M, Ghanta M, Nuthalapati P, Natesh N, Tang J, Bhaskar L. Influence of Exercise on Oxygen Consumption, Pulmonary Ventilation, and Blood Gas Analyses in Individuals with Chronic Diseases. Life 2025, 15: 1255. PMID: 40868903, PMCID: PMC12387642, DOI: 10.3390/life15081255.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPhysical activityVigorous-intensity physical activityWorld Health OrganizationEffects of exercise trainingBalance-training exercisesNon-pharmacological interventionsInfluence of exerciseHeightened metabolic demandsMuscle-strengtheningOxygen consumptionResistance trainingAerobic exerciseExercise trainingModerate-intensityLifestyle factorsIndividual life expectancyOlder adultsCardiopulmonary healthHealthcare systemType 2 diabetesChronic diseasesPulmonary ventilationExercisePsychological issuesBody compositionBiosensing Technologies to Improve Neurological Disease Management
Nuthalapati P, Singh A, Desai B, Yendapalli P, Gongireddy R, Singh K, Bollu B, Pinninty D. Biosensing Technologies to Improve Neurological Disease Management. 2025, 401-421. DOI: 10.1002/9781394287697.ch13.Chapters
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