Neima Briggs, MD, PhD
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About
Research
Publications
2026
Helminths as architects of trained tolerance: implications for human health
Moroz Q, Souza JLN, Briggs N. Helminths as architects of trained tolerance: implications for human health. Clinical & Translational Immunology 2026, 15: e70086. DOI: 10.1002/cti2.70086.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHelminths as architects of trained tolerance: implications for human health
Moroz Q, Souza J, Briggs N. Helminths as architects of trained tolerance: implications for human health. Clinical & Translational Immunology 2026, 15 DOI: 10.1002/cti2.70086.Peer-Reviewed Original ResearchHelminths as Architects of Trained Tolerance: Implications for Human Health
Moroz Q, Souza J, Briggs N. Helminths as Architects of Trained Tolerance: Implications for Human Health. Clinical & Translational Immunology. Accepted with minor revisions.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsA high-dose hookworm infection model uncovers acquired protective mechanisms not engaged by vaccination.
Briggs N, Moroz Q, Vidyarthi A, Siniscalco E, Chen S, Versteeg L, De Oliveira A, Pollet J, Craft J. A high-dose hookworm infection model uncovers acquired protective mechanisms not engaged by vaccination. Manuscript in submission.Peer-Reviewed Original Research
2025
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025, 58: 3075-3093.e6. PMID: 41253159, PMCID: PMC12834128, DOI: 10.1016/j.immuni.2025.10.022.Peer-Reviewed Original ResearchThis study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.A Honduran Prevalence Study on Soil-Transmitted Helminths Highlights Serological Antibodies to Tm-WAP49 as a Diagnostic Marker for Exposure to Human Trichuriasis.
Briggs N, Versteeg L, Mejia R, Pollet J, Villar M, Zhan B, Segal G, Novak S, Lenihan P, Musgrave P, Ellis V, Coello C, Sastry K, Craft J, Hotez P, Bottazzi M. A Honduran Prevalence Study on Soil-Transmitted Helminths Highlights Serological Antibodies to Tm-WAP49 as a Diagnostic Marker for Exposure to Human Trichuriasis. American Journal Of Tropical Medicine And Hygiene 2025, 112: 1017-1025. PMID: 39933187, PMCID: PMC12062693, DOI: 10.4269/ajtmh.24-0514.Peer-Reviewed Original ResearchSoil-Transmitted HelminthsReceiver-operating characteristic analysisSerological assaysFecal examinationDiagnostic toolIndirect ELISAGold standard testRoundworm infectionDiseases of humansRecombinant proteinsValidation cohortScreening cohortActive infectionInfections rankControl seraHuman trichuriasisDiagnostic markerRelationship to chronic diseasesClinical questionsWestern blottingDiagnostic potentialInfectionWhipwormCharacteristic analysisPrevalence studiesAltering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
De Oliveira A, Versteeg L, Briggs N, Adhikari R, Villar M, Redd J, Hotez P, Bottazzi M, Pollet J. Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. PLOS Neglected Tropical Diseases 2025, 19: e0012809. PMID: 39792959, PMCID: PMC11756802, DOI: 10.1371/journal.pntd.0012809.Peer-Reviewed Original ResearchConceptsAntigen-specific antibodiesMRNA vaccine candidateMRNA vaccinesVaccine candidatesNa-GST-1Plasma membrane-anchoredRobust CD8+ T-cell responsesCD8+ T cell responsesMemory T cell populationsTiters of antigen-specific antibodiesLevels of antigen-specific antibodiesT cell responsesT cell populationsRecombinant Na-GST-1In vivo efficacySubunit vaccine candidateInduce humoral responsesImmunogenicity findingsNeutralizing antibodiesClinical studiesDevelopment of multivalent vaccinesHumoral responseRNA vaccinesImmune responsePeptide presentation
2024
The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even Z, Meli A, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky D, Kong Y, Wang Y, Waizman D, Rice T, De Kumar B, Wang X, Palm N, Craft J, Basu M, Ghosh S, Rothlin C. The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response. Immunity 2024, 57: 1893-1907.e6. PMID: 39096910, PMCID: PMC11421571, DOI: 10.1016/j.immuni.2024.07.006.Peer-Reviewed Original ResearchT cell receptorImmune responseNaive CD4+ T cellsCD4+ T cellsIFN-IHelminth infectionsNippostrongylus brasiliensis infectionDecreased immune responseType I interferonNaive TT cellsMemory-likeUnrelated antigensTranscriptional changesExtracellular matrixSPF miceCell receptorsI interferonGerm-freeResponse to certain environmental cuesInfectionMiceFunctional changesCell transcriptional statesTranscriptional heterogeneity
2023
Response to comment on “Dosing implications for liposomal amphotericin B in pregnancy”
O'Grady N, Davis M, McManus D, Topal J, Azar M, Briggs N. Response to comment on “Dosing implications for liposomal amphotericin B in pregnancy”. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2023, 43: 992-992. PMID: 37701938, DOI: 10.1002/phar.2864.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDosing implications for liposomal amphotericin B in pregnancy
O'Grady N, McManus D, Briggs N, Azar M, Topal J, Davis M. Dosing implications for liposomal amphotericin B in pregnancy. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2023, 43: 452-462. PMID: 36862037, DOI: 10.1002/phar.2784.Peer-Reviewed Original ResearchConceptsIdeal body weightLiposomal amphotericin BMucocutaneous leishmaniasisBody weightAmphotericin BInfectious Diseases SocietyTotal body weightPregnant patientsDiseases SocietyAmerica guidelinesPreferred agentPregnancyParasitic infectionsOpportunistic fungalAdverse effectsPatientsTreatmentLeishmaniasisLambsDaysUse of lambsGuidelinesRegimensWeightFetuses
Academic Achievements & Community Involvement
Clinical Care
Overview
Neima Briggs, MD, PhD, is an internist and infectious diseases specialist with advanced training and clinical experience in tropical and travel medicine. He is a founding member of the Yale Travel and Tropical Medicine Clinic at the Yale Center for Infectious Diseases, where he provides comprehensive clinical services to both individuals seeking pre-travel advice and medical services, as well as the management of a broad spectrum of infectious illnesses.
Dr. Briggs serves as a clinical instructor at Yale School of Medicine and conducts active research studying host immune responses to parasitic infections, aiming to elucidate mechanisms of disease progression and develop novel diagnostics, therapeutics, and vaccines. He maintains ongoing research collaborations in Brazil and Honduras.
Dr. Briggs earned his medical and doctorate degrees from the University of Texas Medical School at Houston. He completed residency training in internal medicine, a fellowship in infectious diseases, and postdoctoral research fellowship in immunobiology at Yale School of Medicine.
He also holds a diploma in tropical medicine from the National School of Tropical Medicine at Baylor College of Medicine and a Certificate of Knowledge in Clinical Tropical Medicine and Travelers’ Health (CTropMed) from the American Society of Tropical Medicine and Hygiene (ASTMH).
His work has been recognized with numerous honors, including a Fulbright Scholarship to Spain, the Burroughs Wellcome Fund/ASTMH Postdoctoral Fellowship in Tropical Medicine to Brazil, the Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award, and the ASTMH Benjamin H. Kean Travel Fellowship to Honduras.
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