Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMohamed Sherif, MBBCh
Assistant Professor Adjunct in PsychiatryAbout
Research
Publications
2025
Cell Type-Specific Vulnerabilities and Drug Effects in Psychiatric Disorders: A Systems-Level Analysis Using sn-RNAseq
Shukla R, Smail M, Chandrasena S, Zhang X, Reddy V, Kelley C, Herman J, Sherif M, McCullumsmith R. Cell Type-Specific Vulnerabilities and Drug Effects in Psychiatric Disorders: A Systems-Level Analysis Using sn-RNAseq. Biological Psychiatry 2025, 97: s15-s16. DOI: 10.1016/j.biopsych.2025.02.051.Peer-Reviewed Original ResearchComputer Modeling of Dynamic and Functional Consequences of Cortical Microcircuit Changes in Psychiatric Disorders: Depression as a Case Study
Khalil M, Sherif M. Computer Modeling of Dynamic and Functional Consequences of Cortical Microcircuit Changes in Psychiatric Disorders: Depression as a Case Study. Biological Psychiatry 2025, 97: s16. DOI: 10.1016/j.biopsych.2025.02.052.Peer-Reviewed Original Research
2024
Prevalence of clinical electroencephalography findings in stroke patients with delirium
Mintz N, Andrews N, Pan K, Bessette E, Asaad W, Sherif M, Rubinos C, Mahta A, Girard T, Reznik M. Prevalence of clinical electroencephalography findings in stroke patients with delirium. Clinical Neurophysiology 2024, 162: 229-234. PMID: 38548493, PMCID: PMC11185045, DOI: 10.1016/j.clinph.2024.03.004.Peer-Reviewed Original ResearchConceptsEpileptiform abnormalitiesEEG abnormalitiesPrevalence of EEG abnormalitiesClinical EEG reportsGeneralized epileptiform abnormalitiesFocal EEG abnormalitiesFocal epileptiform abnormalitiesStroke patientsGeneralized slowingNon-neurological patientsDaily delirium assessmentsFocal slowingAcute cognitive disorderEEG reportsProspective studyElectroencephalography findingsStructural lesionsEEG characteristicsPatientsAbnormalitiesPatient daysDelirium monitoringDeliriumPrevalenceEEG
2023
HNN-core: A Python software for cellular and circuit-level interpretation of human MEG/EEG
Jas M, Thorpe R, Tolley N, Bailey C, Brandt S, Caldwell B, Cheng H, Daniels D, Pujol C, Khalil M, Kanekar S, Kohl C, Kolozsvári O, Lankinen K, Loi K, Neymotin S, Partani R, Pelah M, Rockhill A, Sherif M, Hamalainen M, Jones S. HNN-core: A Python software for cellular and circuit-level interpretation of human MEG/EEG. The Journal Of Open Source Software 2023, 8: 5848. PMID: 38939123, PMCID: PMC11210709, DOI: 10.21105/joss.05848.Peer-Reviewed Original ResearchLocal patchesLong apical dendritesNeural networkPython softwareNeocortical columnsApical dendrites of pyramidal cellsDendrites of pyramidal cellsModeling toolsMagneto-/electro-encephalographyInhibitory neuronsPyramidal cellsSynaptic driveNeurosolverCortical layersIntracellular currentsNetwork-level interactionsPythonNetworkSoftwareMEG/EEGLibraryNeural mechanisms
2022
Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs
Smail M, Chandrasena S, Zhang X, Reddy V, Kelley C, Herman J, Sherif M, McCullumsmith R, Shukla R. Differential vulnerability of anterior cingulate cortex cell types to diseases and drugs. Molecular Psychiatry 2022, 27: 4023-4034. PMID: 35754044, PMCID: PMC9875728, DOI: 10.1038/s41380-022-01657-w.Peer-Reviewed Original ResearchConceptsDeep-layer pyramidal neuronsCell typesPyramidal neuronsCell-type-specific vulnerabilityFunctional profilesFunctional themesPsychiatric disordersCellular eventsDisease statesDrug side effectsCell-specific signaturesVIP interneuronsTherapeutic responseDrug effectsSide effectsTherapeutic strategiesDrug activityDrug profileCellsDisease actionDifferential vulnerabilityDisease profileNeuronsDrugAstrocyte interactions
2021
Integrating single-cell transcriptomics and microcircuit computer modeling
Reddy V, Sherif M, Shukla R. Integrating single-cell transcriptomics and microcircuit computer modeling. Current Opinion In Pharmacology 2021, 60: 34-39. PMID: 34325379, DOI: 10.1016/j.coph.2021.06.006.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsSystems biology-based strategiesBiology-based strategiesGenetic markersCaenorhabditis elegansGene OntologyMolecular detailsTranscriptomePenetrant phenotypeElectrophysiological propertiesBiophysically realistic computer modelNeuronal microcircuitryBiophysical modelCaenorhabditisRealistic computational modelElegansNeuronsGenesBrain microcircuitsPhenotypeOpinion reviewBrain