Lida Moradi
Associate Research ScientistCards
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Research
Publications
2026
Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia D, Waxman S, Fu W, Liu C. Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis. Bioactive Materials 2026, 61: 640-656. PMID: 41799961, PMCID: PMC12963906, DOI: 10.1016/j.bioactmat.2026.02.045.Peer-Reviewed Original ResearchDisease-modifying therapiesIntra-articular deliveryIntra-articular administrationCartilage degenerationTranslational potentialOpen field testSodium channel inhibitorsSustained deliveryThermoresponsive hydrogelPain behaviorCartilage explantsClinical efficacyChannel inhibitorsTherapeutic durabilityLacosamideNav1.7 inhibitorsPainEquivalent doseChondrocyte metabolismClinical translationTherapyTherapeutic targetGene expression analysisHydrogelsDelivery strategies
2025
Investigating the Effect of Two Types of Aerobic Exercise on SIRT1 and AMPK Gene Expression Regulation in an Animal Model of Non-Alcoholic Fatty Liver Disease
Foroughi Rahaghi M, Moradi L, Abedi B, Azarbaijani M. Investigating the Effect of Two Types of Aerobic Exercise on SIRT1 and AMPK Gene Expression Regulation in an Animal Model of Non-Alcoholic Fatty Liver Disease. Journal Of Shahrekord University Of Medical Sciences 2025, 27: 192-199. DOI: 10.34172/jsums.1072.Peer-Reviewed Original ResearchGene expressionGene expression regulationNormal diet feedingExpression of AMPKExpression regulationAMPK pathwayNormal diet conditionsAMPK expressionHFD control groupAMPKModel of non-alcoholic fatty liver diseaseAMPK gene expressionWeeks of treadmill trainingAnimal modelsAnimal models of non-alcoholic fatty liver diseaseTukey's post hoc testEffects of HIITSIRT1GenesWeeks of HFDMale C57BL/6J miceNon-alcoholic fatty liver diseaseTreadmill trainingAerobic exerciseHFDSynergistic Effects of High-Intensity Interval Training and Resveratrol Supplementation on AKT, GDF-11, and HIF-1α Molecular Pathways in the Cardiac Tissue of Aged Wistar Rats
Raziee R, Moradi L, Abedi B, Azarbayjani M. Synergistic Effects of High-Intensity Interval Training and Resveratrol Supplementation on AKT, GDF-11, and HIF-1α Molecular Pathways in the Cardiac Tissue of Aged Wistar Rats. Disease And Diagnosis 2025, 14: 100-106. DOI: 10.34172/ddj.1669.Peer-Reviewed Original ResearchHigh-intensity interval trainingAged Wistar ratsGDF-11Cardiac tissueEffects of high-intensity interval trainingHIF-1aWistar ratsAge-related cardiac declineResveratrol supplementationHIF-1a expressionInterval trainingHigh-intensity interval training protocolMale ratsCardiac declineEndothelial dysfunctionProtein expression levelsTwo-way ANOVAMicrovascular perfusionCombination groupCardioprotective pathwaysAkt levelsSedentary controlsWestern blottingRatsMolecular pathwaysThe Effect of Intensive Combined Exercise on the Lipid Profile and Hepatic Enzymes in Modeling Diet-Induced NAFLD Rats
Mirghani S, Roozbayani M, Rahmati S, Moradi L. The Effect of Intensive Combined Exercise on the Lipid Profile and Hepatic Enzymes in Modeling Diet-Induced NAFLD Rats. Chonnam Medical Journal 2025, 61: 116-121. PMID: 41080213, PMCID: PMC12511808, DOI: 10.4068/cmj.2025.61.3.116.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseEffects of exercise modeAspartate transaminaseExercise modesNonalcoholic steatohepatitisDeterminants of nonalcoholic fatty liver diseaseResistance trainingLow-density lipoprotein (LDL)Male Wistar ratsImprovement of nonalcoholic fatty liver diseaseLevels of TGLiver fat contentAlkaline phosphataseComplication of nonalcoholic fatty liver diseaseFatty liver diseaseNAFLD-induced ratsNo significant differenceLiver functionWistar ratsLipid profileHepatic fibrosisLiver diseaseNormal controlsCombined exerciseAerobic exerciseCorrigendum to “Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications” [Int. J. Biol. Macromol. volume 154 (2020), Pages 1285–1294]
Asadpour S, Kargozar S, Moradi L, Ai A, Nosrati H, Ai J. Corrigendum to “Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications” [Int. J. Biol. Macromol. volume 154 (2020), Pages 1285–1294]. International Journal Of Biological Macromolecules 2025, 306: 141459. PMID: 40037279, DOI: 10.1016/j.ijbiomac.2025.141459.Peer-Reviewed Original ResearchCorrigendum to “Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair” [Int. J. Biol. Macromol. Volume 183(2021), Pages 1327–1345]
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Corrigendum to “Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair” [Int. J. Biol. Macromol. Volume 183(2021), Pages 1327–1345]. International Journal Of Biological Macromolecules 2025, 303: 140586. PMID: 39923490, DOI: 10.1016/j.ijbiomac.2025.140586.Peer-Reviewed Original Research
2024
Culture of Immature Ovarian Follicles within Decellularized Ovary Enhances Oocyte Maturation and Improves In vitro Fertilization Results
Alaee S, Moradi L, Marcu D, Shokri S, Khozani T, Zal F. Culture of Immature Ovarian Follicles within Decellularized Ovary Enhances Oocyte Maturation and Improves In vitro Fertilization Results. West Kazakhstan Medical Journal 2024, 66: 267–284-267–284. DOI: 10.18502/wkmj.v66i3.17214.Peer-Reviewed Original ResearchIn vitro maturationPreantral folliclesMII oocytesIn vitro maturation of oocytesGene expression profilesOvarian folliclesIn vivoGene expression levelsOocyte maturation rateMaturation of ovarian folliclesEnhanced oocyte maturationEmbryo development ratesIn vitro fertilizationFollicles of miceImmature ovarian folliclesMaturation of oocytesExpression level of IGF1RImplantation potentialLevels of IGF1RBlastocystIntegrin AvOocyte maturationOocytesCaspase-3Maturation rate
2023
The Effect of Aerobic Exercise on SREBP-1c Gene Expression in Skeletal Muscle in Obese Female Rats
Eftekharzadeh M, Atashak S, Azarbayjani M, Moradi L, Rahmati-Ahmadabad S. The Effect of Aerobic Exercise on SREBP-1c Gene Expression in Skeletal Muscle in Obese Female Rats. Thrita 2023, 12 DOI: 10.5812/thrita-138382.Peer-Reviewed Original ResearchEffects of aerobic exerciseAerobic exerciseHigh-fat dietSkeletal muscle metabolic disordersObese female ratsTreadmill 5 timesInteractive effects of aerobic exerciseMuscle metabolic disordersHigh-fatFemale ratsAerobic trainingSkeletal muscleQuadriceps muscleSREBP-1c geneSREBP-1c gene expressionNormal dietTraining sessionsMetabolic disordersExerciseSterol regulatory element-binding proteinFemale Wistar ratsWeight of ratsLipid metabolismQuadricepsSREBP-1cDoes Exercise Affect Cancer via Reverse Cholesterol Transport Process? A Hypothesis Which Needs to Be Clarified by Researchers
Rahmati S, Taherkhani H, Zarezadehmehrizi A, Moradi L. Does Exercise Affect Cancer via Reverse Cholesterol Transport Process? A Hypothesis Which Needs to Be Clarified by Researchers. Advanced Pharmaceutical Bulletin 2023, 14: 9-10. PMID: 38585459, PMCID: PMC10997941, DOI: 10.34172/apb.2024.008.Peer-Reviewed Original ResearchInjectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing
Moradi L, Witek L, Vivekanand Nayak V, Cabrera Pereira A, Kim E, Good J, Liu C. Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing. Biomaterials 2023, 301: 122289. PMID: 37639975, PMCID: PMC11232488, DOI: 10.1016/j.biomaterials.2023.122289.Peer-Reviewed Original ResearchConceptsΒ-GP hydrogelPorous interconnected structureAmount of GOTissue engineering applicationsEngineering applicationsLong-term storage stabilityInjectable biomaterialsGrowth factor deliveryInjectable hydrogelsInterconnected structureHigh viscosityRapid sol-gel transitionHydrogelsSustained-release propertiesFactor deliveryBiomechanical environmentStorage stabilitySustained deliverySol-gel transitionExcellent candidateCartilage regenerationGel networkSustained releaseChitosanFracture healing
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