LaShae Nicholson
Postdoctoral Associate (Neuroscience)DownloadHi-Res Photo
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Titles
Postdoctoral Associate (Neuroscience)
Education & Training
- PhD
- Goethe-Universität Frankfurt, Biology / Neuroscience
Research
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Overview
Medical Research Interests
Alzheimer Disease; Metabolic Syndrome
Public Health Interests
Aging; Bioinformatics; Metabolomics
ORCID
0000-0002-5171-181X
Research at a Glance
Yale Co-Authors
Frequent collaborators of LaShae Nicholson's published research.
Publications Timeline
A big-picture view of LaShae Nicholson's research output by year.
Research Interests
Research topics LaShae Nicholson is interested in exploring.
Stephen Strittmatter, MD, PhD, AB
Takuya Toyonaga, MD, PhD
Jason Cai, PhD
Daniel Holden
Yiyun Huang, PhD
Hideyuki Takahashi, PhD
13Publications
383Citations
Alzheimer Disease
Publications
2025
Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8
Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8 Ramakrishnan Kannan, Xingxing Wang, LaShae Nicholson, Nancy Z. Lin, Elisa M. Howard, Atrayee Basu, Ines Ingabire, Yuichi Sekine, Stephen M. Strittmatter bioRxiv 2025.10.10.681747; doi: https://doi.org/10.1101/2025.10.10.681747Peer-Reviewed Original ResearchInsulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.
Nicholson L, Tang SJ, Karra T, Abouelatta H, Strittmatter SM. Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes. BioRxiv 2025 PMID: 40964391, DOI: 10.1101/2025.09.05.674487.Peer-Reviewed Original Research
2023
PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s Disease
Zheng C, Nicholson L, Chen B, Toyonaga T, Liu M, Strittmatter S, Carson R, Huang Y, Cai Z. PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.081695.Peer-Reviewed Original ResearchConceptsAPP/PS1 micePS1 miceWT miceCentral nervous systemTime-activity curvesAlzheimer's diseaseAPP/PS1 transgenic miceAPP/PS1 transgenic AD miceMouse brainAge-matched WT controlsPS1 transgenic miceAPP/PS1Transgenic AD miceDynamic PET imaging dataROCK2 protein expressionAD drug discoveryHigh tracer uptakeMin post injectionPET imaging resultsExpression levelsReference tissue model 2PET imaging dataProtein expression levelsAD miceRegional time-activity curvesNeuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Stoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter S. Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein. Alzheimer's Research & Therapy 2023, 15: 201. PMID: 37968719, PMCID: PMC10647125, DOI: 10.1186/s13195-023-01345-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSynapse lossDKI miceTau accumulationBrain immune activationNeural network dysfunctionPhospho-tau accumulationAccumulation of tauNeuronal genesInflammatory markersAD miceAβ levelsPrion proteinDystrophic neuritesImmune activationTau pathologyNeuronal gene expressionAmyloid-β OligomersGliotic reactionNetwork dysfunctionBehavioral deficitsSynaptic failureAD modelMemory impairmentAlzheimer's diseaseFunction of age
2022
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Science Translational Medicine 2022, 14: eabi8593. PMID: 35648810, PMCID: PMC9554345, DOI: 10.1126/scitranslmed.abi8593.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographySilent allosteric modulatorsAlzheimer's diseaseMouse modelPhospho-tau accumulationAged mouse modelAlzheimer mouse modelImmune-mediated attackSAM treatmentMicroglial mediatorsSynaptic engulfmentSynaptic lossAD miceComplement component C1qSynapse lossGlutamate responseSynaptic densityDrug washoutSynaptic localizationTherapeutic benefitCognitive impairmentAllosteric modulatorsEmission tomographyNonhuman primatesComponent C1q
2020
Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment
Nicholson L, Gervasi N, Falières T, Leroy A, Miremont D, Zala D, Hanus C. Whole-Cell Photobleaching Reveals Time-Dependent Compartmentalization of Soluble Proteins by the Axon Initial Segment. Frontiers In Cellular Neuroscience 2020, 14: 180. PMID: 32754013, PMCID: PMC7366827, DOI: 10.3389/fncel.2020.00180.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSoluble proteinAxon initial segmentCytoplasmic soluble proteinsForm of compartmentalizationIntact F-actinSuper-resolution fluorescence imagingSpectrin cytoskeletonSpecific proteinsF-actinProtein accumulationAxonal compartmentProtein exchangeProteinCompartmentalizationSomatodendritic compartmentNeuronal morphologyInitial segmentImportant insightsUltrastructureCompartmentsFluorescence imagingPhotobleachingCytoskeletonSignalingDifferentiation
2019
VEGF/VEGFR2 signaling regulates hippocampal axon branching during development
Luck R, Urban S, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. ELife 2019, 8: e49818. PMID: 31868583, PMCID: PMC6927742, DOI: 10.7554/elife.49818.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVEGF/VEGFR2Hippocampal axonsAxon branchingVEGF/VEGFR2 signalingHippocampal neurons resultsMouse hippocampal neuronsCA1 neuronsFunctional synapsesCA3 regionHippocampal neuronsNeurons resultsAngiogenic factorsHippocampus developmentAxonsReceptor VEGFR2NeuronsVEGFR2Neuronal networksVEGFNumber of filopodiaVEGFR2 signalingEphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
Harde E, Nicholson L, Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, de Almodóvar C, Acker-Palmer A. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. ELife 2019, 8: e49819. PMID: 31868584, PMCID: PMC6927743, DOI: 10.7554/elife.49819.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVascular endothelial growth factorLong-term potentiationDendritic arborizationCircuitry developmentSpine morphogenesisSpine head sizeEndothelial growth factorVEGFR2 internalizationCA3 synapsesCA3 regionDendritic arborsSpine maturationCompound miceHippocampal neuronsDendritic branchingNervous systemAngiogenic factorsEndothelial cellsGrowth factorNeuronsVEGFR2ArborizationMiceFunctional crosstalkEphrinB2
2017
Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury
Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, Blesch A. Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia 2017, 60: 167-180. PMID: 28735026, DOI: 10.1016/j.actbio.2017.07.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBrain-derived neurotrophic factorHost spinal cordSpinal cord injurySpinal cordLesion siteSchwann cellsBDNF expressionCord injuryNeurotrophic factorAxonal regenerationBDNF deliveryExpression of BDNFGraft/host interfaceSpinal cord lesion siteAdult mammalian central nervous systemHost/graft interfaceSpinal cord transectionMammalian central nervous systemRat spinal cordCentral nervous systemCaudal spinal cordCaudal injectionHemisection lesionCord transectionCell transplantation
2013
Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord
Sandner B, Rivera FJ, Caioni M, Nicholson L, Eckstein V, Bogdahn U, Aigner L, Blesch A, Weidner N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem Cell Research 2013, 11: 758-771. PMID: 23770801, DOI: 10.1016/j.scr.2013.05.003.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsBone Marrow TransplantationBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationFemaleHumansImmunohistochemistryMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeural Stem CellsOligodendrogliaRatsRats, Inbred F344Rats, Sprague-DawleyRats, TransgenicSpinal Cord InjuriesConceptsGrafted neural progenitor cellsNeural progenitor cellsBone marrow stromal cellsAdult neural progenitor cellsOligodendroglial differentiationSpinal cordEffect of BMSCsAdult Fischer 344 ratsLoss of oligodendrogliaProgenitor cellsSpinal cord injuryFischer 344 ratsAdult bone marrowOligodendrogenic effectFunctional recoveryCord injuryLesion cavityInjury siteMarrow stromal cellsBone marrowStromal cellsOligodendrogliaBone morphogenetic protein 2/4Rapid upregulationVivo experiments
Academic Achievements & Community Involvement
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Honors
honor BRAINS Fellow
09/01/2024Other AwardUniversity of WashingtonDetailsUnited Stateshonor Career MODE Fellow
03/01/2024Other AwardColumbia UniversityDetailsUnited Stateshonor Kavli Postdoctoral Fellowship
10/13/2023Yale University AwardKavliDetailsUnited States
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