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INFORMATION FOR

    Katherine DeStefano, MD, MS

    Associate Professor of Neurology
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    Additional Titles

    Medical Director of the Multiple Sclerosis/Interventional Immunology Center

    About

    Titles

    Associate Professor of Neurology

    Medical Director of the Multiple Sclerosis/Interventional Immunology Center

    Biography

    Dr. DeStefano is an associate professor in the Department of Neurology and serves as Medical Director of the Interventional Immunology Center at Yale. Dr. DeStefano graduated summa cum laude from Indiana University, where she obtained a BS in Biology and an MS in Education. She obtained her doctorate degree at Weill Cornell Medical College of Cornell University and then went on to complete a residency in neurology at Yale University School of Medicine, where she served as a chief resident. She then completed a fellowship in Multiple Sclerosis at Yale prior to joining the Yale faculty. Dr. DeStefano is board certified and involved in several clinical research trials at the Yale MS Center.

    Last Updated on November 07, 2025.

    Appointments

    • Neurology

      Associate Professor on Term
      Primary

    Other Departments & Organizations

    Education & Training

    MS Fellow
    Yale-New Haven Hospital (2015)
    Chief Resident
    Yale-New Haven Hospital (2014)
    Resident
    Yale-New Haven Hospital (2013)
    MD
    Weill Cornell Medical College (2010)
    MS
    Indiana University, Master of Science in Education (2000)
    BS
    Indiana University, Biology (1997)

    Clinical Care

    Overview

    Katherine DeStefano, MD, MS, is a neurologist who primarily cares for patients in the Yale Medicine Multiple Sclerosis Program. She also treats other immune mediated diseases that affect the central nervous system, such as neuromyelitis optica (NMO), an uncommon syndrome affecting the optic nerves and spinal cord.

    “I had a family member diagnosed with a debilitating neurologic disorder at a relatively young age,” Dr. DeStefano says. “That experience piqued my interest in the field and gave me better insight into what it means to be both the patient and family member of a loved one diagnosed with a chronic neurologic illness.”


    She likes to put patients at ease by explaining that multiple sclerosis is not the same disease it was 15 or even 10 years ago. Neurologists now have an expansive list of medications that can prevent disease progression. “We can actually do a great deal to treat patients with multiple sclerosis and change the course of their disease, which is incredibly gratifying to see,” she says.Dr. DeStefano is an assistant professor of neurology at Yale School of Medicine.

    Clinical Specialties

    Neurology; Multiple Sclerosis

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