José Jaime Martínez-Magaña, BSc, MSc, PhD
he/him/his
Postdoctoral AssociateDownloadHi-Res Photo
About
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Titles
Postdoctoral Associate
Departments & Organizations
Education & Training
- Research Assistant
- National Institute of Genomic Medicine (2021)
- PhD
- Universidad Juarez Autonoma de Tabasco, Doctor in Biomedical sciences (2020)
- MSc
- Universidad Nacional Autonoma de Mexico, Master in Biochemical Sciences (2017)
- Research Assistant
- National Institute of Genomic Medicine (2015)
- Research Internship
- Mexican Institute of Social Services (2013)
- BSc
- National Autonomous University of Mexico, Pharmaceutical and Biological Chemist (2012)
- Research Intership
- Center for Research and Advanced Studies (2007)
Advanced Training & Certifications
- Single-Cell RNA-Sequencing Data Analysis
- Memorial Sloan Kettering (2024)
- Getting Started with Python
- Yale University (2023)
- Analyzing and Visualizing Data with Python
- Yale University (2022)
- Advance Gene Mapping
- The Rockefeller University (2022)
- NIH Grant Writing Boot Camp
- Columbia University (2022)
Research
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Overview
Public Health Interests
Mental Health; Network Analysis; Genetics, Genomics, Epigenetics; Aging; Bioinformatics; Statistical Computing; Substance Use, Addiction
ORCID
0000-0003-0390-8252- View Lab Website
Montalvo-Ortiz Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of José Jaime Martínez-Magaña's published research.
Publications Timeline
A big-picture view of José Jaime Martínez-Magaña's research output by year.
Janitza Montalvo-Ortiz, PhD
Brenda Cabrera-Mendoza, MD, PhD
Diana Núñez
John Krystal, MD
Joel Gelernter, MD
Matthew Girgenti, PhD
93Publications
710Citations
Publications
Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphismA phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
Jennings M, Martínez-Magaña J, Courchesne-Krak N, Cupertino R, Vilar-Ribó L, Bianchi S, Hatoum A, Atkinson E, Giusti-Rodriguez P, Montalvo-Ortiz J, Gelernter J, Artigas M, 23andMe I, Aslibekyan S, Auton A, Babalola E, Bell R, Bielenberg J, Bryc K, Bullis E, Coker D, Partida G, Dhamija D, Das S, Elson S, Eriksson N, Filshtein T, Fitch A, Fletez-Brant K, Fontanillas P, Freyman W, Granka J, Heilbron K, Hernandez A, Hicks B, Hinds D, Jewett E, Jiang Y, Kukar K, Kwong A, Lin K, Llamas B, Lowe M, McCreight J, McIntyre M, Micheletti S, Moreno M, Nandakumar P, Nguyen D, Noblin E, O'Connell J, Petrakovitz A, Poznik G, Reynoso A, Schumacher M, Shastri A, Shelton J, Shi J, Shringarpure S, Su Q, Tat S, Tchakouté C, Tran V, Tung J, Wang X, Wang W, Weldon C, Wilton P, Wong C, Elson S, Edenberg H, Fontanillas P, Palmer A, Sanchez-Roige S. A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine 2024, 103: 105086. PMID: 38580523, PMCID: PMC11121167, DOI: 10.1016/j.ebiom.2024.105086.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMultiple domains of healthDomains of healthEffects of alcohol consumptionAlcohol consumptionHealth outcomesPhenome-wide association studyAlcohol-related behaviorsCardio-metabolic healthPotential causal effectMendelian randomisation studiesGenome-wide association studiesPhenome-wide associationMR analysisPheWAS associationsMultiple domainsHypothesis-free approachPreventive medicineDiverse cohortPheWASAssociation studiesHealthReproductive healthAlcohol behaviorConsequences of drinkingEuropean cohortPsychiatric genetics in the diverse landscape of Latin American populations
Bruxel E, Rovaris D, Belangero S, Chavarría-Soley G, Cuellar-Barboza A, Martínez-Magaña J, Nagamatsu S, Nievergelt C, Núñez-Ríos D, Ota V, Peterson R, Sloofman L, Adams A, Albino E, Alvarado A, Andrade-Brito D, Arguello-Pascualli P, Bandeira C, Bau C, Bulik C, Buxbaum J, Cappi C, Corral-Frias N, Corrales A, Corsi-Zuelli F, Crowley J, Cupertino R, da Silva B, De Almeida S, De la Hoz J, Forero D, Fries G, Gelernter J, González-Giraldo Y, Grevet E, Grice D, Hernández-Garayua A, Hettema J, Ibáñez A, Ionita-Laza I, Lattig M, Lima Y, Lin Y, López-León S, Loureiro C, Martínez-Cerdeño V, Martínez-Levy G, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares A, Oliveira V, Ormond R, Palmer A, Panzenhagen A, Passos-Bueno M, Peng Q, Pérez-Palma E, Prieto M, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis F, Sharp R, Storch E, Tavares M, Tietz G, Torres-Hernández B, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan E, Velásquez M, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Santoro M, Nicolini H, Atkinson E, Giusti-Rodríguez P, Montalvo-Ortiz J. Psychiatric genetics in the diverse landscape of Latin American populations. Nature Genetics 2025, 57: 1074-1088. PMID: 40175716, PMCID: PMC12133068, DOI: 10.1038/s41588-025-02127-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome-wide association studiesPsychiatric genomicsPsychiatric genome-wide association studiesLarge-scale genome-wide association studiesGenetic risk lociNon-European populationsGenetic diversityRisk lociGenetic admixtureBurden of psychiatric disordersAssociation studiesPsychiatric disordersEuropean ancestryPsychiatric geneticsGenomeHealthcare disparitiesConsortium effortLatin American populationsPromote equityEnvironmental factorsDiversityAmerican populationDiverse landscapeLociAncestry
2026
Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review
Cabrera-Mendoza B, Panzenhagen A, de Anda-Jáuregui G, He J, Magalhaes P, Martínez-Magaña J, Martínez-Levy G, Qiu D, Sotelo D, Torres D, Medrano J, Vidal G, Velásquez M, Nicolini H, Polimanti R, Kaster M, Docherty A, Kimbrel N, Genis-Mendoza A, Ito L, Shansis F, Rovaris D, Folego-Temoteo I, Fries G, Consortium S. Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review. Biological Psychiatry 2026 PMID: 41539590, PMCID: PMC12969891, DOI: 10.1016/j.biopsych.2025.12.009.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGenomic studiesGenomic researchEpigenetic studiesFunctional annotation resourcesMolecular studiesAncestry-specific lociStress response pathwaysPolygenic score studiesGenome-wideQ-Genie toolImmune-related processesQ-GenieGene studiesSystematic reviewTranscriptomic markersMeta-analysesBiology of suicidal behaviorStudies of suicidal ideationRandom-effects meta-analysesNonsuicidal Self-InjuryAnnotation resourcesRisk of biasNewcastle-Ottawa ScaleStudy of suicideHispanic/Latinx individuals
2025
Pharmacogenomic architecture of attention deficit/hyperactivity disorder in Latin-American subjects
Torres S, Genis A, Nicolini J, Martínez-Magaña J, Garzón-Rodríguez N. Pharmacogenomic architecture of attention deficit/hyperactivity disorder in Latin-American subjects. Journal Of The Neurological Sciences 2025, 480: 124582. DOI: 10.1016/j.jns.2025.124582.Peer-Reviewed Original ResearchMapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Li H, Liu Y, Shi Y, Wang J, Nguyen T, Xie Y, Zheng W, Cheng Y, Cruz D, Modliszewski J, Terwilliger R, Sliby A, Martínez-Magaña J, Montalvo-Ortiz J, Roache J, Averill L, Young-McCaughan S, Shiroma P, Huber B, Lewis D, Glausier J, Holtzheimer P, Friedman M, Zhang J, Peterson A, Abdallah C, Valizadeh A, Zhang X, Xu K, Krystal J, Duman R, Zhao H, Corcoran D, Williamson D, Girgenti M. Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain. Biological Psychiatry 2025 PMID: 41192574, PMCID: PMC12862789, DOI: 10.1016/j.biopsych.2025.10.032.Peer-Reviewed Original ResearchAltmetricConceptsFear circuitryDNA methylationPost-traumatic stress disorderNeurobiology of PTSDTraumatic stress exposureDepressive disorder casesGene expressionSevere psychological traumaKetamine trialsPTSD patientsKetamine efficacyUnique biologyStress disorderDNA methylation signaturesCell typesMental disordersStress exposureSubcortical regionsPTSDPsychological traumaDisorder casesRNA-seqEpigenetic variationMethylation dataReference panelWhole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
Wang L, Nuñez Y, Martínez-Magaña J, Rivera-Hernandez M, Mao Z, Brennand K, Montalvo-Ortiz J, Kranzler H, Gelernter J, Zhou H. Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. Translational Psychiatry 2025, 15: 380. PMID: 41052974, PMCID: PMC12500996, DOI: 10.1038/s41398-025-03578-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWhole-exome sequencing studiesGenetic architectureRisk variantsGene-based collapsing testCross-ancestry meta-analysisContribution of rare coding variantsGenome-wide association studiesWhole-exome sequencing dataRare Coding VariantsLow-frequency variantsParticipants of European ancestryLoss-of-functionExome variantsCross-ancestrySequence dataOpioid dependenceAssociation studiesMissense variantsTop genesEuropean ancestrySuggestive associationsRare variantsAfrican ancestryFunctional studiesYale-Penn57. A META-ANALYSIS OF SCHIZOPHRENIA SPECTRUM DISORDERS: BRIDGING THE GAP AND LEARNING WITH LATIN AMERICAN COHORTS
Belangero S, Martins A, Kajitani G, Almodobar L, Ota V, Bruxel E, Ormond R, Ito L, Mendoza A, Loureiro C, Chavarria-Soley G, Martínez-Magaña J, Raventós H, Nicolini H, Giusti-Rodriguez P. 57. A META-ANALYSIS OF SCHIZOPHRENIA SPECTRUM DISORDERS: BRIDGING THE GAP AND LEARNING WITH LATIN AMERICAN COHORTS. European Neuropsychopharmacology 2025, 99: 83. DOI: 10.1016/j.euroneuro.2025.08.162.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPsychiatric geneticsSchizophrenia spectrum disordersLatin American populationsPsychiatric genomicsGenome-wide association study catalogGenetic basisPrecision mental healthPost-GWAS analysisMeta-analysisTissue-specific enrichmentGenome-wide significanceGene set sizeCause of disabilityAmerican populationErbB signaling pathwayHealth disparitiesMental healthFine-mappingFunctional annotationRisk lociAssociation studiesComplex psychiatric conditionsGenomic controlHealth landscapeGut Microbiota Composition in Rats Consuming Sucralose or Rebaudioside A at Recommended Doses Under Two Dietary Interventions
Ramos-García M, Genis-Mendoza A, García-Vázquez C, Martínez-Magaña J, Olvera-Hernández V, Martínez-López M, Díaz-Zagoya J, Alvarez-Villagomez C, Juárez-Rojop I, Nicolini H, Ble-Castillo J. Gut Microbiota Composition in Rats Consuming Sucralose or Rebaudioside A at Recommended Doses Under Two Dietary Interventions. Metabolites 2025, 15: 529. PMID: 40863148, PMCID: PMC12388177, DOI: 10.3390/metabo15080529.Peer-Reviewed Original ResearchConceptsGut microbiotaHigh-fat dietNon-nutritive sweetenersNormal dietAssociated with gut microbiotaRibosomal RNA gene sequencingGut microbiota compositionRNA gene sequencingMale Wistar ratsRecommended doseTaxonomic levelsGene sequencesPhylum levelMicrobiota compositionArtificial non-nutritive sweetenerGM compositionWistar ratsDietary interventionClinical relevanceFecal samplesRatsReb ADoseMicrobial analysisDietary conditions
Academic Achievements & Community Involvement
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Activities
activity BMC Psychiatry
02/01/2026 - PresentJournal ServiceEditorial Board Memberactivity Informatics in Medicine Unlocked
2020 - PresentJournal ServiceRevieweractivity The World Journal of Biological Psychiatry
2021 - PresentJournal ServiceRevieweractivity Behavioral Sciences
2023 - PresentJournal ServiceRevieweractivity International Journal of Environmental Research and Public Health
2022 - PresentJournal ServiceReviewer
Honors
honor NIAAA Early Carrer Investigator Travel Award
10/15/2024Other AwardWorld Congress of Psychiatric GeneticsDetailsSingaporehonor Kavli Postdoctoral Award for Academic Diversity
01/16/2023Yale University AwardKavli Institute for Neuroscience at YaleDetailsUnited Stateshonor National Investigator Level I
10/29/2021International AwardNational Council of Science and TechnologyDetailsMexicohonor SHARP Professional Development scholarship
07/19/2021National AwardColumbia UniversityDetailsUnited Stateshonor Research Assistant Fellowship
06/01/2021International AwardNational Council of Science and TechnologyDetailsMexico
Teaching & Mentoring
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Teaching
Didactic CB&B 755 Bioinformatics
LecturerLecture SettingDetails9/1/2024 - PresentForUndergraduate6 Average Instructional Hours Per Year
Mentoring
Miguel Angel Ramos Mendez
Graduate student2026 - PresentRafaella Ormond Sampaio
Postgrad associate2025 - PresentDavid Ruiz Ramos
Graduate student2025 - PresentMelody Rivera-Hernández
Graduate student2025 - Present
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Contacts
Locations
VA Connecticut Healthcare Errera Community Care Center - Orange Annex
Academic Office
200 Edison Road
Orange, CT 06477