Jiaqi Guo

My research focuses on how nanoscale structures drive bacterial motility and interact with host cells. In Vibrio cholerae, the pathogen that causes cholera, a single polar flagellum powers rapid swimming and contributes to infection. I am using cryo-electron microscopy to reveal the structural basis of the flagellar motor and its associated proteins, and thus the molecular mechanisms of flagellar movement. In parallel, I integrate imaging across multiple scales – from cryo-EM and cryo-electron tomography to super-resolution fluorescence and live-cell microscopy – to study dynamic nano-bio interactions in their cellular context.