Hesham Mukhtar, MBBS
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Postdoctoral AssociateDownloadHi-Res Photo
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Postdoctoral Associate
Biography
Hesham Mukhtar, MBBS is a Postdoctoral Associate at Yale Department of Psychiatry, working within the PRIME Clinic at Connecticut Mental Health Center (CMHC). His research focuses on the use of antipsychotic medications in youth at clinical high risk (CHR) for psychosis, with an emphasis on patient-centered treatment approaches.
Hesham earned his MBBS from King Edward Medical University. Following his medical training, he moved to the United States to pursue his passion for psychiatry and to practice as a physician-scientist.
His work centers on schizophrenia spectrum disorders and early intervention, aiming to improve outcomes for young individuals at risk of developing psychosis. He also maintains a strong interest in medical education and is committed to advancing the field through clinically meaningful research.
Last Updated on March 26, 2026.
Appointments
Psychiatry
Postdoctoral AssociatePrimary
Other Departments & Organizations
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
Education & Training
- MBBS
- King Edward Medical University (2021)
Research
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Overview
Medical Research Interests
Psychiatry and Psychology; Schizophrenia; Schizophrenia Spectrum and Other Psychotic Disorders
Public Health Interests
Behavioral Health; Community Health; Mental Health
ORCID
0009-0007-5298-4063- View Lab Website
PRIME Clinic
Research at a Glance
Yale Co-Authors
Frequent collaborators of Hesham Mukhtar's published research.
Scott Woods, MD
Tyrone Cannon
Albert Powers, MD, PhD
Emily Farina, PhD
John Cahill, MD, PhD
Oluwole Jegede, MD, MPH, PhD
Publications
2026
Substance use disorders among young adults in North-Western Nigeria: descriptive survey of patterns of use.
Marke C, Jegede O, Mukhtar H, Ojo A, Boman Y, Yakasai B, Dike C. Substance use disorders among young adults in North-Western Nigeria: descriptive survey of patterns of use. BJPsych International 2026, 1-8. PMID: 41669148, PMCID: PMC12885046, DOI: 10.1192/bji.2025.10092.Peer-Reviewed Original ResearchConceptsSubstance use disordersDescriptive surveyNorth-Western NigeriaSubstance Involvement Screening TestUse disorderCross-sectional surveyBurden of substance use disordersPublic health campaignsPublic health challengeDrug use disordersYoung adult populationPublic health concernNon-medical reasonsHealth campaignsOdds of substance usePrevention resourcesTobacco smokeHealth challengesSub-Saharan AfricaAdult populationHealth concernSubstance useHeavy drinkersPast-yearPrescription drugs
2025
Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics
Farina E, Mourgues-Codern C, Stimler K, Kenney J, Saxena A, Mukhtar H, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Ellman L, Gold J, Keshavan M, Mathalon D, Mittal V, Perkins D, Schiffman J, Silverstein S, Strauss G, Stone W, Walker E, Waltz J, Corlett P, Powers A, Woods S. Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics. Schizophrenia 2025, 11: 123. PMID: 41053030, PMCID: PMC12501016, DOI: 10.1038/s41537-025-00663-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskClinical high-risk samplesNorth American Prodrome Longitudinal StudyOvert psychotic disordersSample characteristicsSample of individualsNegative symptomsPsychotic disordersPsychosis riskSelf-referralRecruitment sourcesBetween-study differencesComputerized assessmentHierarchical regressionPsychosisRecruitment source effectsClinical implicationsLongitudinal studyGeneral symptomsDemographic differencesClinical profileSymptomsParticipantsClinical heterogeneitySexCASE REPORT OF SEVERE NEUROINVASIVE WEST NILE ENCEPHALITIS CAUSING COMA AND DEATH
MUKHTAR L, OGANESYAN A, WALZ D, QADIR S, MUKHTAR H, LAKE M. CASE REPORT OF SEVERE NEUROINVASIVE WEST NILE ENCEPHALITIS CAUSING COMA AND DEATH. Chest 2025, 168: a2430-a2431. DOI: 10.1016/j.chest.2025.07.1405.Peer-Reviewed Original ResearchPrediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. PMID: 40842369, PMCID: PMC12404330, DOI: 10.1017/s0033291725101372.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiation571. Preliminary Findings on the Association Between Psychotropic Medication and Symptom Profile Changes in Youth at Clinical High Risk for Psychosis
Zhou Q, Ananth A, Yuan E, Ku B, Goldsmith D, Addington J, Bearden C, Cadenhead K, Mukhtar H, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. 571. Preliminary Findings on the Association Between Psychotropic Medication and Symptom Profile Changes in Youth at Clinical High Risk for Psychosis. Biological Psychiatry 2025, 97: s333-s334. DOI: 10.1016/j.biopsych.2025.02.810.Peer-Reviewed Original Research
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Connecticut Mental Health Center
Lab
34 Park Street
New Haven, CT 06519