Henrique Novaes Morgan, MSc
Postgraduate AssociateAbout
Research
Publications
2025
Control of hepatic gluconeogenesis in mice fed a high protein diet: a transcriptional shift from CREB to FoxO1
Camargo Neto J, Morgan H, Moro M, Assis A, Ruiz L, Schavinski A, Lautherbach N, Navegantes L, Kettelhut I. Control of hepatic gluconeogenesis in mice fed a high protein diet: a transcriptional shift from CREB to FoxO1. AJP Endocrinology And Metabolism 2025, 329: e810-e824. PMID: 41134648, DOI: 10.1152/ajpendo.00242.2025.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseCorticosteroneCyclic AMP Response Element-Binding ProteinDietary ProteinsForkhead Box Protein O1GluconeogenesisHepatocyte Nuclear Factor 4InsulinLiverMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphorylationSignal TransductionTranscription, GeneticConceptsHepatic gluconeogenesisHP-fed miceControl of hepatic gluconeogenesisMolecular mechanismsRegulatory landscapeCREB activationBranched-chain amino acidsImpaired insulin signalingHepatic metabolic adaptationRegulation of hepatic glucose productionHepatic FoxO1Transcriptional coactivatorTranscriptional programsInsulin signalingGluconeogenic capacityTranscriptional shiftHP-fedRegulatory pathwaysSignaling pathwayHepatic glucose productionCAMP/PKA/CREB signaling pathwayRegulatory factorsMetabolic adaptationAmino acidsElevated corticosterone levelsShort-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats
Spiller P, Morgan H, Navegantes L, Machado B, da Silva M, Moraes D. Short-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats. American Journal Of Physiology - Cell Physiology 2025, 328: c1346-c1365. PMID: 40094217, DOI: 10.1152/ajpcell.00967.2024.Peer-Reviewed Original ResearchConceptsSensitivity to acute hypoxiaSustained hypoxiaGlomus cellsChronic activationAcute hypoxiaCarotid bodyMitochondrial proteinsCell subpopulationsVoltage-gated K+ channelsCarotid body glomus cellsMolecular mechanismsContent of mitochondrial proteinsMolecular mechanisms of plasticityType II cellsElectron transport chainATP releaseElectrophysiological propertiesArterial chemoreceptorsII cellsMembrane potentialTransport chainHypoxiaKrebs cycleNeurotransmitter releaseExperimental modelHepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD
Alves E, Santos J, Cruz A, Camargo F, Talarico C, Santos A, Silva C, Morgan H, Matos S, Araujo L, Camporez J. Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD. Pathophysiology 2025, 32: 1. PMID: 39846638, PMCID: PMC11755535, DOI: 10.3390/pathophysiology32010001.Peer-Reviewed Original ResearchHigh-fat dietMetabolic protective effectsRegular chowAAV-treatedConclusions:Overexpression of ERasResults:Protective effect of estrogenAssociated with cardiometabolic riskEffects of estrogenEstrogen receptor alphaMale C57BL/6J miceHFD-fed miceCardiometabolic riskC57BL/6J miceHepatic insulin sensitivityLiver diseaseMetabolic healthReceptor alphaBody fatSteatotic liver diseaseInsulin resistanceInsulin sensitivityCultured primary hepatocytesMice
2024
Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold
Morgan H, Delfino H, Schavinski A, Malone S, Charoy C, Reis N, Assis A, Lautherbach N, Silveira W, Heck L, Guton D, Domingos A, Kettelhut I, Montminy M, Navegantes L. Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold. Metabolism 2024, 157: 155940. PMID: 38878857, DOI: 10.1016/j.metabol.2024.155940.Peer-Reviewed Original ResearchConceptsCREB coactivator CRTC2Active gluconeogenesisRegulation of gluconeogenesisUpregulation of gluconeogenesisGlucagon-stimulated gluconeogenesisPKA-mediated phosphorylationGluconeogenic programGluconeogenic genesPhosphorylation of CREBCREB/CRTC2CRTC2GluconeogenesisGlucose homeostasisDephosphorylationMouse liverPathwayBundle architectureNoradrenergic innervationSympathetic inputTranscriptionGenesCentral angiotensin-(1–7) attenuates hypoglycemia in sepsis-like conditions via reducing systemic and hepatic inflammation
Cardoso Santos G, Alves de Jesus A, Passaglia P, Novaes Morgan H, Carvalho Navegantes L, Leico Kagohara Elias L, Cárnio E. Central angiotensin-(1–7) attenuates hypoglycemia in sepsis-like conditions via reducing systemic and hepatic inflammation. Cytokine 2024, 179: 156637. PMID: 38723454, DOI: 10.1016/j.cyto.2024.156637.Peer-Reviewed Original ResearchConceptsAng-(1Systemic inflammationPlasma concentrationsHepatic inflammationIL-6Deleterious effects of lipopolysaccharideMale Wistar-Hannover ratsSepsis-like conditionWistar Hannover ratsAng-(1-7Concentrations of TNF-aInadequate host responseEffects of lipopolysaccharideAnti-inflammatory actionSeptic patientsNeuroimmune pathwaysCentralized treatmentHannover ratsOrgan failureHepatic IL-6IL-10TNF-aIL-1BDeleterious effectsMetabolic dysfunctionMaternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner
Schavinski A, Reis N, Morgan H, Assis A, Moro M, Valentim R, Seni-Silva A, Ramos E, Kettelhut I, Navegantes L. Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner. International Journal Of Molecular Sciences 2024, 25: 4136. PMID: 38673723, PMCID: PMC11050228, DOI: 10.3390/ijms25084136.Peer-Reviewed Original ResearchConceptsMaternal vitamin D deficiencyVitamin D-deficient maleVitamin D deficiencySerum calcidiol levelsCalcidiol levelsOffspring ratsD deficiencyImpact of maternal vitamin D deficiencyPDX1Adult male offspring ratsVitamin D deficiency statusVitamin D-deficient femalesEndocrine pancreas developmentFunction of B cellsLong-term metabolic changesMale offspring ratsInsulin secretionResponse to different glucose concentrationsFemale offspringPromoter regionMethylation profilesSex-dependent mannerSerum insulin levelsLower insulin secretionGene expression
2022
Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats
Assis A, Silva K, Lautherbach N, Morgan H, Garófalo M, Zanon N, Navegantes L, Chaves V, do Carmo Kettelhut I. Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats. Lipids 2022, 57: 313-325. PMID: 36098349, DOI: 10.1002/lipd.12358.Peer-Reviewed Original ResearchConceptsATP citrate lyaseGlycerol-3-PBrown adipose tissueRespiratory chain protein complexesEnzymes of de novo fatty acid synthesisInterscapular brown adipose tissueContent of mitochondrial proteinsPentose phosphate pathwayGlycerokinase activityPhosphorylation of glycerolFatty acid synthesisActivity of glycerokinaseGlucose-6-phosphate dehydrogenaseLipid contentPyruvate incorporationMitochondrial proteinsBrown adipose tissue of ratsFatty acidsGlucose-6-phosphatePhosphate pathwayProtein complexesCitrate lyaseTriacylglycerol synthesisPhosphoenolpyruvate carboxykinase activityAcid synthesisMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats
Reis N, Assis A, Lautherbach N, Gonçalves D, Silveira W, Morgan H, Valentim R, Almeida L, Heck L, Zanon N, Koike T, Santos A, Miyabara E, Kettelhut I, Navegantes L. Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats. Journal Of Cachexia Sarcopenia And Muscle 2022, 13: 2175-2187. PMID: 35582969, PMCID: PMC9398225, DOI: 10.1002/jcsm.12986.Peer-Reviewed Original ResearchConceptsFast-twitch skeletal muscleVitamin D deficiencyOffspring ratsD deficiencyEx vivo contractionMaternal vitamin D deficiencySkeletal muscleSlow-twitch skeletal muscleCompensatory increaseAdult offspring ratsMale offspring ratsMaternal vitamin DFemale offspring ratsProtein levelsFemale offspringPhosphorylation levelsCross-sectional areaMuscle contentLevels of MyoDVDD dietFemale ratsProtein levels of myoDWistar-HannoverVitamin DMyogenic activity
2021
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice
Schavinski A, Machado J, Morgan H, Lautherbach N, Paula-Gomes S, Kettelhut I, Navegantes L. Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice. Peptides 2021, 146: 170677. PMID: 34695513, DOI: 10.1016/j.peptides.2021.170677.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideCalcitonin gene-related peptide in vivoInjection of calcitonin gene-related peptideGene-related peptideCultured neonatal cardiomyocytesHearts of miceCentral nervous systemHeart miceC57B16 miceNeonatal cardiomyocytesVasodilator peptideMouse heartsMetabolic profileCardiac muscleFasted miceFoxO phosphorylationAcute effectsPeripheral tissuesMiceCatabolic effectsNervous systemKinase-1Autophagic fluxCalcitoninPhosphorylation levelsMolecular basis of Period 1 regulation by adrenergic signaling in the heart
Jesus I, Araújo F, Mesquita T, Júnior N, Silva M, Morgan H, Silva K, Silva C, Birbrair A, Amaral F, Navegantes L, Salgado H, Szawka R, Poletini M, Guatimosim S. Molecular basis of Period 1 regulation by adrenergic signaling in the heart. The FASEB Journal 2021, 35: e21886. PMID: 34473369, DOI: 10.1096/fj.202100441r.Peer-Reviewed Original ResearchConceptsPer1 expressionPer1 mRNAMolecular basisB-adrenergic receptorsB ARGene expression in vivoB2-ARInhibitors of ERK1/2Expression in vivoIsoproterenol inductionAdrenergic inputSympathetic denervationNE levelsUpstream of ERK1/2ERK1/2 phosphorylationMyocardial processesPer1 transcriptionClock machineryIsoproterenolAdrenergic signalingPER1 oscillationsCircadian clockNocturnal riseISO inductionClock genes
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