Haiying Zhan, MD, PhD
Assistant Professor of PathologyCards
About
Research
Publications
2026
140 Clinicopathologic Analyses of 34 Cases of High-Grade Serous-Like Carcinoma (HG-SL-Ca) of the Breast
Haw Y, Krings G, Hsiao W, Zhan H, Hou Y, Zhang G, Zhang H, Wei S, Lae M, Post M, Shamir E, Liu Y, Yang W, Siziopikou P, Schnitt S, Chen Y, Li X. 140 Clinicopathologic Analyses of 34 Cases of High-Grade Serous-Like Carcinoma (HG-SL-Ca) of the Breast. Laboratory Investigation 2026, 106: 104419. DOI: 10.1016/j.labinv.2025.104419.Peer-Reviewed Original Research150 Pathologic Characterization of Non-Mass Enhancement Lesions of the Breast in MRI-Guided Core Biopsies
Jordan T, Liang Y, Krishnamurti U, Lewin J, Zhan H. 150 Pathologic Characterization of Non-Mass Enhancement Lesions of the Breast in MRI-Guided Core Biopsies. Laboratory Investigation 2026, 106: 104429. DOI: 10.1016/j.labinv.2025.104429.Peer-Reviewed Original Research204 Estimating Breast Tumor Size from Histologic Section Involvement: A Correlative Study with Imaging and Gross Pathology
Salehiazar S, Moideen P, Zhan H, Ai D, Krishnamurti U, Liang Y. 204 Estimating Breast Tumor Size from Histologic Section Involvement: A Correlative Study with Imaging and Gross Pathology. Laboratory Investigation 2026, 106: 104483. DOI: 10.1016/j.labinv.2025.104483.Peer-Reviewed Original Research193 Can Histologic Features of Flat Epithelial Atypia Distinguish Cases with and without Co-Existing Ductal Carcinoma In Situ (DCIS)?
Perera N, Zhan H, Ai D, Du J, Krishnamurti U, Liang Y. 193 Can Histologic Features of Flat Epithelial Atypia Distinguish Cases with and without Co-Existing Ductal Carcinoma In Situ (DCIS)? Laboratory Investigation 2026, 106: 104472. DOI: 10.1016/j.labinv.2025.104472.Peer-Reviewed Original Research149 Largest Ductal Diameter as a Histopathologic Predictor of DCIS Extent in Resection Specimens
Jordan T, Liang Y, Krishnamurti U, Zhan H. 149 Largest Ductal Diameter as a Histopathologic Predictor of DCIS Extent in Resection Specimens. Laboratory Investigation 2026, 106: 104428. DOI: 10.1016/j.labinv.2025.104428.Peer-Reviewed Original ResearchClinicopathologic Analyses of 34 Cases of High-Grade Serous-Like Carcinoma (HG-SL-Ca) of the Breast.
Haw Y, Krings G, Hsiao W, Zhan H, Hou Y, Zhang G, Zhang H, Wei S, Yang W, Laé M, Post M, Liu Y, Shamir E, Rosa M, Siziopikou K, Schnitt S, Chen Y, Li X. Clinicopathologic Analyses of 34 Cases of High-Grade Serous-Like Carcinoma (HG-SL-Ca) of the Breast. The American Journal Of Surgical Pathology 2026 PMID: 41735183, DOI: 10.1097/pas.0000000000002516.Peer-Reviewed Original ResearchPathological complete responseAberrant p53 expressionLocal recurrenceTumor sizeP53 expressionAssociated with shorter metastasis-free survivalPathologic complete response rateAssociated with worse overall survivalAxillary lymph node metastasisShorter metastasis-free survivalER-/HER2+GATA-3 stainingWell-formed tubulesMetastasis-free survivalLymph node metastasisFollow-up dataER+/HER2+Nuclear WT1ER-/HER2-Complete responseNeoadjuvant chemotherapyDistant metastasisOverall survivalNuclear gradeBreast carcinomaQuantitative Assays for TROP2 Measurement in Breast Cancer and Comparison to H-Score
He M, Chan N, Liu M, Robbins C, Bates K, Benanto J, Colón-Cartagena L, Kahila M, Zhan H, Krishnamurti U, Moutafi M, Yaghoobi V, Liebler D, Fulton R, Rimm D. Quantitative Assays for TROP2 Measurement in Breast Cancer and Comparison to H-Score. Applied Immunohistochemistry & Molecular Morphology 2026, 34: 143-154. PMID: 41709478, PMCID: PMC13143368, DOI: 10.1097/pai.0000000000001311.Peer-Reviewed Original ResearchTrophoblast cell surface antigen 2Trophoblast cell surface antigen 2 expressionH-scoreBreast cancerQuantitative immunofluorescenceSacituzumab govitecanPathologists' readingsTNBC cohortAntibody-drug conjugate targetsExpression of trophoblast cell surface antigen 2H-score methodSolid tumor typesBreast cancer cohortBreast cancer biopsiesYale-New Haven HospitalBreast cancer samplesCompanion diagnostic testsSurface antigen 2H-score assessmentTumor typesClinical outcomesNew Haven HospitalCancer biopsiesTumor samplesCancer cohort
2025
Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers
Foldi J, Xiong K, Liu M, Robbins C, Chen F, Zhan H, Burela S, Dai J, Karn P, Dugo M, Bianchini G, Lee A, Oesterreich S, Rimm D, Pusztai L. Mixed Molecular Subtypes Coexist in Estrogen Receptor Heterogeneous Primary Breast Cancers. JCO Precision Oncology 2025, 9: e2500529. PMID: 41237360, DOI: 10.1200/po-25-00529.Peer-Reviewed Original ResearchConceptsPrimary breast cancerBreast cancerMolecular subtypesClinical outcomesEstrogen receptor (ER)-negativeClinical outcomes of patientsHigh recurrence scoreOutcomes of patientsTumor cell populationDigital spatial profilingMolecular featuresER-highER-lowPreoperative chemotherapyER-negativeER-positiveRecurrence scoreER expressionEndocrine-resistantEndocrine resistanceChemotherapy strategiesChemotherapy sensitivityIntratumoral heterogeneityPositive cellsER heterogeneityInvasive breast carcinoma in a patient with PHTS: a case report
Zhan H, Fischbach N, Lynch M, Liang Y, Krishnamurti U, Cohen P. Invasive breast carcinoma in a patient with PHTS: a case report. Diagnostic Pathology 2025, 20: 120. PMID: 41107919, PMCID: PMC12532417, DOI: 10.1186/s13000-025-01715-1.Peer-Reviewed Original ResearchConceptsPTEN hamartoma tumor syndromeAtypical ductal hyperplasiaHamartoma tumor syndromeTumor syndromeFamily historyBilateral palpable breast massesFocal atypical ductal hyperplasiaFamily history of cancerInvasive breast carcinomaPalpable breast massesEctopic breast tissueBloody nipple dischargeAxillary lymph nodesGermline pathogenic variantsHistory of cancerCase presentationWeInvasive carcinomaBreast carcinomaDuctal hyperplasiaMastectomy specimensNipple dischargeRight breastBenign papillomasMultiple biopsiesPapillary proliferationInterobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study
Korie U, Ai D, Podany P, Zhang H, Zhan H, Kahila M, Colon-Cartagena L, Wei S, Sun H, Du J, Krishnamurti U, Liang Y. Interobserver agreement and histologic analysis of atypical ductal hyperplasia bordering on ductal carcinoma in situ: A multi-institutional study. American Journal Of Clinical Pathology 2025, 164: 704-711. PMID: 40994034, DOI: 10.1093/ajcp/aqaf088.Peer-Reviewed Original ResearchConceptsDuctal carcinoma in situAtypical ductal hyperplasiaCarcinoma in situSpindle-shaped nucleiAssociated with carcinomaIndividual histologic featuresHistological featuresInterobserver agreementDuctal hyperplasiaBreast pathologistsBiopsy casesCases of atypical ductal hyperplasiaLow-grade ductal carcinoma in situEpithelial cellsClinical follow-up dataLesion extentHistological analysisDiagnostic gray zoneMulti-institutional studyVariable interobserver agreementFollow-up dataModerate to substantial agreementDuct involvementHistologic reviewRadiological findings